Recent Advances in the Synthesis of Difluorinated Architectures from Trifluoromethyl Groups
Recent Advances in the Synthesis of Difluorinated Architectures from Trifluoromethyl Groups
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三氟甲基合成二氟结构的最新进展
DOI：
10.1002/adsc.202101234
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发表时间：
2021-11
影响因子：
5.4
通讯作者：
Zuo Zuo
中科院分区：
文献类型：
--
作者：
Feng Zhao;Wenlong Zhou;Zuo Zuo
含氟基团广泛应用于医药、农化和材料领域。因此，这些结构在有机合成和药物化学领域引起了极大的兴趣。在各种氟化基团中，二氟甲基单元由于其独特的药物性质而受到越来越多的关注。近年来，多种二氟甲基化化合物的合成方法得到迅速发展。然而，这些方法大多数使用过量的二氟甲基化试剂处理芳香族化合物，其中通常含有有机金属化合物，因此这些转化通常不太环保和原子经济。在这篇综述中，我们总结了通过单 C(sp3)−F 键断裂从三氟甲基化芳香族化合物或三氟甲基烯烃合成二氟甲基基序或二氟烯烃的新方法的最新进展。
Fluorine‐containing moieties are widely used in the pharmaceutical, agrochemical, and material fields. Thus, these structures are of immense interest in the fields of organic synthesis and medicinal chemistry. Among various fluorinated groups, the difluoromethyl unit has drawn increasing attention due to its unique pharmaceutical properties. In recent years, several methods for the synthesis of difluoromethylated compounds have been rapidly developed. However, most of these methods treat aromatic compounds with excess difluoromethylating reagents, which often contain organometallic compounds, so these transformations are generally less environmentally friendly and atom‐economical. In this review, we summarize the recent development of new methods for the synthesis of difluoromethyl motifs or difluoroalkenes from trifluoromethylated aromatic compounds or trifluoromethyl alkenes via single C(sp3)−F bond cleavage.