Relationships between circadian measures, depression, and response to antidepressant treatment: A preliminary investigation.
Relationships between circadian measures, depression, and response to antidepressant treatment: A preliminary investigation.
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DOI：
10.1016/j.psychres.2017.03.010
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发表时间：
2017-06
影响因子：
11.3
通讯作者：
Todd Arnedt J
中科院分区：
文献类型：
--
作者：
Swanson LM;Burgess HJ;Huntley ED;Bertram H;Mooney A;Zollars J;Dopp R;Hoffmann R;Armitage R;Todd Arnedt J
很少有研究探讨昼夜节律和单相抑郁症之间的关系。此外，迄今为止还没有研究将昼夜节律标志物作为抑郁症治疗反应的预测因素。在本研究中，我们研究了昼夜节律时间与睡眠和抑郁严重程度之间的关系，30名成年重度抑郁症患者完成了一项随机对照试验，在氟西汀之前进行了两周的卧床时间（TIB）限制，重点是性别差异。30名患有重度抑郁症的成年人接受了8周的氟西汀20-40 mg，并在前2周随机分配至8h TIB或6 h TIB。6小时TIB条件的参与者被进一步随机分配到延迟就寝或提前起床组。昼夜节律测量包括昏暗光褪黑激素起始（DLMO）和DLMO与睡眠中期点之间的差异（即，相位角差）。采用汉密尔顿抑郁评定量表评估抑郁。对于女性，氟西汀治疗2周后的相位延迟和实验性TIB操作与氟西汀反应较差相关，抑郁严重程度与相位角差呈负相关，而男性抑郁严重程度与相位角差呈正相关。
Few studies have examined relationships between circadian rhythms and unipolar major depressive disorder. Further, no study to date has examined circadian markers as predictors of response to depression treatment. In the present study, we examined associations between circadian timing and its alignment with sleep and depression severity in 30 adults with major depressive disorder who completed a randomized controlled trial of two weeks of time in bed (TIB) restriction administered adjunctive to fluoxetine, with a focus on sex differences. Thirty adults with major depressive disorder received 8 weeks of fluoxetine 20–40 mgs and were randomized to 8h TIB or 6h TIB for the first 2 weeks. Participants in the 6h TIB condition were further randomized to a delayed bedtime or advanced risetime group. Circadian measures included dim light melatonin onset (DLMO) and the difference between DLMO and midsleep point (i.e., phase angle difference). Depression was assessed using the Hamilton Rating Scale for Depression. For females, a phase delay after 2 weeks of fluoxetine and the experimental TIB manipulation was associated with a poorer response to fluoxetine, and depression severity was negatively correlated with phase angle difference, whereas males showed a positive correlation between depression severity and phase angle difference.