MECHANISM OF ACTIVATION OF THE TGF-BETA RECEPTOR
MECHANISM OF ACTIVATION OF THE TGF-BETA RECEPTOR
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DOI：
10.1038/370341a0
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发表时间：
1994-08-04
期刊：
影响因子：
64.8
通讯作者：
MASSAGUE, J
中科院分区：
文献类型：
--
作者：
WRANA, JL;ATTISANO, L;MASSAGUE, J
转化生长因子-β（TGF-β）通过接触两种称为受体I和II的远距离相关的跨膜丝氨酸/苏氨酸激酶来发出信号。这些分子在信号传导中的作用现已确定。TGF-β直接与受体II结合，受体II是一种组成型活性激酶。然后结合的TGF-β被受体I识别，受体I被募集到复合物中并被受体II磷酸化。磷酸化允许受体I将信号传播到下游底物。这提供了一种细胞因子可以产生信号级联的第一步的机制。
Transforming growth factor-beta (TGF-beta) signals by contacting two distantly related transmembrane serine/threonine kinases called receptors I and II. The role of these molecules in signalling has now been determined. TGF-beta binds directly to receptor II, which is a constitutively active kinase. Bound TGF-beta is then recognized by receptor I which is recruited into the complex and becomes phosphorylated by receptor II. Phosphorylation allows receptor I to propagate the signal to downstream substrates. This provides a mechanism by which a cytokine can generate the first step of a signalling cascade.