Regulation of inhibin synthesis in the rat ovary.
Regulation of inhibin synthesis in the rat ovary.
复制标题
大鼠卵巢抑制素合成的调节。
DOI：
10.1146/annurev.ph.52.030190.004111
复制
发表时间：
1990
影响因子：
18.2
通讯作者：
Mayo,KE
中科院分区：
文献类型：
--
作者：
Woodruff,TK;Mayo,KE
雌性啮齿动物的寿命以生殖轴激素调节的动态变化为特征。从青春期动物的卵巢卵泡开始生长，到发情周期的招募、排卵和黄体化，到妊娠的静止卵泡发育，最终到卵泡衰竭，卵泡的结构、激素反应、类固醇分泌、抑制素和激活素的合成都发生了巨大的变化。在脑下垂体的生物合成功能和荷尔蒙反应方面也可能发生类似的变化。图3以示意性的方式总结了一些关于大鼠生殖生命过程中抑制素表达的信息，这些信息显示了不同生殖状态下血清FSH、卵巢抑制素的产生和卵泡发育的变化。根据最近关于卵巢抑制素表达作为生殖状态的函数的观察，关于维持哺乳动物生殖周期所必需的类固醇和多肽激素之间复杂相互作用的部分图景开始浮出水面。对抑制素基因家族和其他促卵泡激素调节激素的研究可能会进一步加深我们对正常生殖过程和生殖障碍的理解。
The lifespan of the female rodent is characterized by dynamic changes in the hormonal regulation of the reproductive axis. From the time ovarian follicular growth is initiated in peripubertal animals, through recruitment, ovulation and luteinization during the estrous cycle, to the quiescent follicular development of pregnancy, and ultimately to follicular exhaustion, tremendous changes in follicular architecture, hormonal responsiveness, steroid secretion, and inhibin and activin synthesis occur. Similar changes in both the biosynthetic functions and hormonal responsiveness of the pituitary are likely to occur. Some of the information on inhibin expression during the reproductive life-span of the rat reviewed here is summarized in a schematic fashion in Figure 3, which presents changes in serum FSH, ovarian inhibin production, and follicular development during different reproductive states. From recent observations regarding ovarian inhibin expression as a function of reproductive status, a partial picture of the complex interactions between steroid and peptide hormones necessary to maintain reproductive cyclicity in mammals is beginning to emerge. Study of the inhibin gene family and of other FSH-regulatory hormones is likely to further enhance our understanding of both normal reproductive processes and of reproductive disorders.