Polymorphisms in genes modulating the dopamine system: do they inf luence outcome and response to medication after traumatic brain injury?
Polymorphisms in genes modulating the dopamine system: do they inf luence outcome and response to medication after traumatic brain injury?
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DOI：
10.1097/htr.0b013e3181996e6b
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发表时间：
2009-01
期刊：
影响因子：
--
通讯作者：
McAllister TW
中科院分区：
文献类型：
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作者：
McAllister TW
IN CLINICAL PRACTICE, it is common to see different functional outcomes in individuals with similar degrees of traumatic brain injury (TBI) and comparable preinjury intellectual, educational, and functional capabilities. Similarly, individual responses to medications can vary enormously. These differences suggest that environmental and other host factors play important roles in outcome. Host genotype might be one such factor. Our knowledge of the role of genetic factors in response to trauma and recovery from trauma, including reactivity to drugs, is in its infancy. However, some important preliminary findings are emerging (eg, see references 1 and 2). This article focuses on candidate polymorphic alleles in genes modulating central dopaminergic function to illustrate some of the underlying principles and prospects for the future.
