An exploration of the periodontitis-cancer association
An exploration of the periodontitis-cancer association
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DOI：
10.1016/s1047-2797(02)00425-8
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发表时间：
2003-05-01
影响因子：
5.6
通讯作者：
Weiss, NS
中科院分区：
文献类型：
--
作者：
Hujoel, PP;Drangsholt, M;Weiss, NS
目的：牙周炎与多种全身性疾病的发生有关。本研究的目的是探讨在NHANES I流行病学随访Study.METHODS：数据可用于11,328名成年人，年龄25至74岁，被诊断为牙齿个体牙周炎（n = 2092），牙龈炎（n = 2603），健康的牙周组织。（n = 2，671），或在随访开始时作为无牙个体（缺牙n = 3，962）。主要结果的措施是致命的癌症，确定从死亡certification.RESULTS：与健康的牙周组织的个人相比，致命的癌症的发生与牙周炎在基线呈正相关（年龄和性别调整的比值比= 1.55，95%置信区间：1.25-1.92）。在不同的癌症类型中，肺癌表现出最强的相关性。在调整已知的肺癌危险因素后，牙周炎和肺癌之间的关联程度在1.48（95%置信区间：0.88-2.50）和1.73（95%置信区间：1.01-2.97）。牙周炎和肺癌死亡率之间的关系可以确定以上和已知的肺癌危险因素的调整。尽管有这些明显的无混淆的关联，但有理由相信牙周炎与癌症的关联可能是虚假的。(C)2003年爱思唯尔公司All rights reserved.
PURPOSE: Periodontitis has been linked to the occurrence of various systemic diseases. The goal of this study was to explore the periodontitis-cancer association in the NHANES I Epidemiologic Follow-up Study.METHODS: Data were available on 11,328 adults, age 25 to 74 years, who were diagnosed as dentate individuals with either periodontitis (n = 2092), gingivitis (n = 2603), a healthy periodontium. (n = 2,671), or as individuals without teeth (edentulous n = 3,962) at the beginning of the follow-up. The main outcome measure was fatal cancer, as ascertained from death certificates.RESULTS: Compared with individuals with a healthy periodontium, fatal cancer occurrence was positively associated with periodontitis at baseline (age and gender adjusted odds ratio = 1.55, 95% confidence interval: 1.25-1.92). Of the different cancer types, lung cancer demonstrated the strongest association. After adjustment for known risk factors for lung cancer, the magnitude of the association between periodontitis and lung cancer ranged between 1.48 (95% confidence interval: 0.88-2.50) and 1.73 (95% confidence interval: 1.01-2.97).CONCLUSIONS: Associations between periodontitis and lung cancer mortality can be identified above and beyond adjustment for known risk factors for lung cancer. Despite these apparent unconfounded associations, there are reasons to believe that the periodontitis-cancer associations may be spurious. (C) 2003 Elsevier Inc. All rights reserved.