Metabolic and mitochondrial effects of antiretroviral drug exposure in pregnancy and postpartum: Implications for fetal and future health
Metabolic and mitochondrial effects of antiretroviral drug exposure in pregnancy and postpartum: Implications for fetal and future health
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DOI：
10.1016/j.siny.2012.10.005
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发表时间：
2013-02-01
影响因子：
3
通讯作者：
Rakhmanina, Natella
中科院分区：
文献类型：
--
作者：
Kirmse, Brian;Baumgart, Stephen;Rakhmanina, Natella
抗逆转录病毒药物（ARV）对于治疗和预防人类免疫缺陷病毒感染是不可或缺的。尽管在怀孕前、怀孕期间和怀孕后使用它们对母亲和儿童来说是安全的，但人们仍然担心它们的长期健康后果以及它们对脂质、葡萄糖、中间代谢和线粒体代谢的影响。本文回顾了抗逆转录病毒药物对大分子和线粒体代谢的已知影响，以及与妊娠期间能量代谢异常相关的潜在孕产妇、胎儿、新生儿和成人健康风险。正在提供有关加强对受影响人群中这些风险的监测的建议。 (c) 2012 Elsevier Ltd. 保留所有权利。
Antiretroviral drugs (ARVs) are indispensable in the treatment and prevention of human immunodeficiency virus infection. Although their use before, during and after pregnancy is considered safe for mother and child, there are still lingering concerns about their long-term health consequences and the ramifications of their effects on lipid, glucose, intermediary and mitochondrial metabolism. This article reviews the known effects of ARVs on macromolecular and mitochondrial metabolism as well as the potential maternal, fetal, neonatal and adult health risks associated with abnormal energy metabolism during gestation. Recommendations about enhanced monitoring for these risks in affected populations are being provided. (c) 2012 Elsevier Ltd. All rights reserved.