Passive Event-Related Potentials to a Single Tone in Treatment-Resistant Depression, Generalized Anxiety Disorder, and Borderline Personality Disorder Patients
Passive Event-Related Potentials to a Single Tone in Treatment-Resistant Depression, Generalized Anxiety Disorder, and Borderline Personality Disorder Patients
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DOI：
10.1097/wnp.0000000000000091
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发表时间：
2014-10
影响因子：
2.4
通讯作者：
Shaofang Xu;H. Chai;Jing Hu;You Xu;Wanzhen Chen;Wei Wang
中科院分区：
文献类型：
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作者：
Shaofang Xu;H. Chai;Jing Hu;You Xu;Wanzhen Chen;Wei Wang
目的：难治性抑郁症与人格障碍或焦虑障碍共病;被动注意力在这些障碍中的作用仍然未知。单一的音调诱发事件相关电位P3成分（被动P3）可能有助于表征这些障碍的被动注意。研究方法：被动P3测试应用于32例难治性抑郁症，35例广泛性焦虑症，21例边缘性人格障碍，以及31名健康志愿者。Zung抑郁和焦虑自评量表被用来测量这些参与者各自的抑郁和焦虑水平。结果：两组患者的抑郁、焦虑评分均显著高于对照组。难治性抑郁症和广泛性焦虑症患者的P3波幅显著降低，而边缘型人格障碍患者和健康对照者的P3波幅则无显著降低。健康对照组的焦虑水平与P3波幅呈负相关，而其他组无显著性差异。结论：本研究没有区分难治性抑郁症和广泛性焦虑症的被动P3，但表明有一个广泛的被动注意力障碍，在这些疾病。
Purpose: Treatment-resistant depression is comorbid with personality or anxiety disorder; how passive attention functions in these disorders remains unknown. A single tone–elicited event-related potential P3 component (passive P3) might help to characterize the passive attention in these disorders. Methods: The passive P3 test was applied to 32 patients with treatment-resistant depression, 35 with generalized anxiety disorder, and 21 with borderline personality disorder, as well as to 31 healthy volunteers. The Zung Self-rating Depression and Anxiety Scales were used to measure the respective depression and anxiety levels in these participants. Results: All patients scored significantly higher on depression and anxiety than the healthy participants did. P3 amplitude was significantly reduced in groups with treatment-resistant depression and generalized anxiety disorder but not in the group with borderline personality disorder or healthy controls. Anxiety level was negatively correlated with P3 amplitude in healthy controls rather than in other groups. Conclusions: This study did not discriminate treatment-resistant depression and generalized anxiety disorder regarding the passive P3 but suggested that there was a generalized impairment of passive attention in these disorders.