IL-6 Is Associated with Progression of Coronary Artery Calcification and Mortality in Incident Dialysis Patients.
IL-6 Is Associated with Progression of Coronary Artery Calcification and Mortality in Incident Dialysis Patients.
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DOI：
10.1159/000518652
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发表时间：
2021
影响因子：
4.2
通讯作者：
Rosas SE
中科院分区：
文献类型：
--
作者：
Roy N;Rosas SE
炎症在动脉粥样硬化的发病机制中起重要作用。白细胞介素6(IL-6)升高与心血管事件有关，也可预测慢性肾脏疾病(CKD)患者的死亡率。我们的目标是确定IL-6、FGF23和hsCRP对既往无冠状动脉事件的透析患者CAC进展和死亡率的关系。一组预期的成人透析参与者在基线和至少12个月后通过心电触发的多玻片计算机体层摄影(MSCT)扫描测量CAC。在基线访问时检测血脂、矿物质代谢标志物、FGF23和炎症标志物，如IL-6和高敏C反应蛋白(hs-CRP)。IL-6水平高的受试者基线CAC得分最高[133.25(10.35-466.15)]，而IL-6水平较低的受试者[0.25(0-212.2)]和中等受试者的CAC得分[29.55(0-182.85)]。与IL-6水平低[8/32(25%)]和中等IL-6水平[9/32(28.1%)]相比，超过三分之一IL-6高水平的参与者[32人中15人(46.9%)]经历了冠状动脉钙化的进展(p=0.05)。IL-6的每对数增加与死亡率的增加相关(危险比2.2，95%可信区间1.2至3.8；p=0.01)。在调整了吸烟、年龄、性别、种族、糖尿病、磷酸盐和基线钙评分后，IL-6(LOG)与死亡增加2.2倍(95%CI，1.1至4.6；p=0.03)相关。IL-6与透析患者冠状动脉钙化的进展和死亡率有关。
Inflammation is important in the pathogenesis of atherosclerosis. Elevated interleukin-6 (IL-6) is associated with cardiovascular events and also predicts mortality in individuals with chronic kidney disease (CKD). Our goal was to determine the association between IL-6, FGF23 and hsCRP on CAC progression and mortality in incident dialysis patients without prior coronary events. A prospective cohort of incident adult dialysis participants had CAC measured by an ECG-triggered multi-slide computed tomography (MSCT) scans at baseline and at least 12 months later. Lipids, mineral metabolism markers, FGF23, and inflammatory markers, such as IL-6 and high sensitivity C-reactive protein (hs-CRP), were measured at the baseline visit. Participants in the high IL-6 tertile had the highest baseline CAC score [133.25 (10.35-466.15)] compared to the low [0.25 (0-212.2)] and moderate tertiles [29.55 (0-182.85)]. More than one-third of the participants with high IL-6 [15 of 32 (46.9%)] experienced progression of coronary artery calcification compared to participants with low [8 of 32 (25%)] and intermediate IL-6 levels [9 of 32 (28.1%)] (p=0.05). Each log increase in IL-6 was associated with increase in death (hazard ratio 2.2, 95% CI, 1.2 to 3.8; p= 0.01). After adjusting for smoking, age, gender, race, diabetes, phosphate and baseline calcium score, IL-6 (log) was associated with 2.2 times (95% CI, 1.1 to 4.6; p= 0.03) increase in death. IL-6 is associated with progression of coronary artery calcification and mortality in incident dialysis patients.
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DOI：
10.1056/nejmoa0706130
发表时间：
2008-08-07
期刊：
The New England journal of medicine
影响因子：
--
作者：
Gutiérrez OM;Mannstadt M;Isakova T;Rauh-Hain JA;Tamez H;Shah A;Smith K;Lee H;Thadhani R;Jüppner H;Wolf M
通讯作者：
Wolf M
影响因子：
24
作者：
Ridker, Paul M.;MacFadyen, Jean G.;Cornel, Jan H.
通讯作者：
Cornel, Jan H.
影响因子：
13.2
作者：
Rao, M;Guo, DQ;Balakrishnan, VS
通讯作者：
Balakrishnan, VS
影响因子：
6.1
作者：
Jean, Guillaume;Terrat, Jean-Claude;Chazot, Charles
通讯作者：
Chazot, Charles
影响因子：
6.1
作者：
Jung, Hae Hyuk;Kim, Sang-Wook;Han, Heon
通讯作者：
Han, Heon