Coexistence of Avian Influenza Virus H10 and H9 Subtypes among Chickens in Live Poultry Markets during an Outbreak of Infection with a Novel H10N8 Virus in Humans in Nanchang, China
Coexistence of Avian Influenza Virus H10 and H9 Subtypes among Chickens in Live Poultry Markets during an Outbreak of Infection with a Novel H10N8 Virus in Humans in Nanchang, China
复制标题
中国南昌市爆发人类新型 H10N8 病毒感染期间，活禽市场的鸡中禽流感病毒 H10 和 H9 亚型共存
DOI：
10.7883/yoken.jjid.2014.377
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发表时间：
2015-09-01
影响因子：
2.2
通讯作者：
Chen, Haiying
中科院分区：
文献类型：
--
作者：
Hu, Maohong;Li, Xiaodan;Chen, Haiying
人类感染新型H10N8病毒已引起人们对其可能在全球大流行的担忧。在中国南昌报告了第一例H10N8病毒感染病例后，我们报告了该城市活禽市场禽流感病毒（AIVs）的横断面研究结果。2013年12月至2014年1月，在南昌市24家lpm采集的618份标本中，共有201份标本检测出艾滋病病毒阳性。我们发现lpm被aiv严重污染，H9、H10和H5是主要亚型，超过一半的lpm提供了H10亚型阳性的样本。此外，不同亚型的共存在lpm中很常见。201份阳性样本中，有20.9%（42/201）混合感染不同HA亚型的aiv。在42例混合感染中，50%（21/42）显示H9和H10亚型共存，伴有或不伴有H5，且来自鸡样本。这表明H10N8病毒可能起源于H9和H10亚型的片段重组。
Infection with the novel H10N8 virus in humans has raised concerns about its pandemic potential worldwide. We report the results of a cross-sectional study of avian influenza viruses (AIVs) in live poultry markets (LPMs) in Nanchang, China, after the first human case of H10N8 virus infection was reported in the city. A total of 201 specimens tested positive for AIVs among 618 samples collected from 24 LPMs in Nanchang from December 2013 to January 2014. We found that the LPMs were heavily contaminated by AIVs, with H9, H10, and H5 being the predominant subtypes and more than half of the LPMs providing samples that were positive for the H10 subtype. Moreover, the coexistence of different subtypes was common in LPMs. Of the 201 positive samples, 20.9% (42/201) had mixed infections with AIVs of different HA subtypes. Of the 42 mixed infections, 50% (21/42) showed the coexistence of the H9 and H10 subtypes, with or without H5, and were from chicken samples. This indicated that the H10N8 virus probably originated from segment reassortment of the H9 and H10 subtypes.