A pulse of the Drosophila Hox protein abdominal-A schedules the end of neural proliferation via neuroblast apoptosis
A pulse of the Drosophila Hox protein abdominal-A schedules the end of neural proliferation via neuroblast apoptosis
复制标题
DOI：
10.1016/s0896-6273(02)01181-9
复制
发表时间：
2003-01-23
期刊：
影响因子：
16.2
通讯作者：
Gould, AP
中科院分区：
文献类型：
--
作者：
Bello, BC;Hirth, F;Gould, AP
胚后神经母细胞是果蝇中枢神经系统（CNS）的干细胞样前体细胞。它们的分裂能力是沿着体轴的前后方向沿着调节的，但其机制尚不清楚。我们使用在腹部识别的前体细胞的克隆分析表明，神经元的生产停止，因为细胞死亡程序被激活的神经母细胞，而它仍然从事细胞周期。Hox蛋白Abdominal-A（AbdA）的爆发表达指定了细胞凋亡发生的时间，从而决定了每个神经母细胞产生的后代的最终数量。这些研究确定了Hox轴向模式系统与神经增殖的联系机制，这涉及前体细胞死亡的时间调节，而不是细胞周期。
Postembryonic neuroblasts are stem cell-like precursors that generate most neurons of the adult Drosophila central nervous system (CNS). Their capacity to divide is modulated along the anterior-posterior body axis, but the mechanism underlying this is unclear. We use clonal analysis of identified precursors in the abdomen to show that neuron production stops because the cell death program is activated in the neuroblast while it is still engaged in the cell cycle. A burst of expression of the Hox protein Abdominal-A (AbdA) specifies the time at which apoptosis occurs, thereby determining the final number of progeny that each neuroblast generates. These studies identify a mechanism linking the Hox axial patterning system to neural proliferation, and this involves temporal regulation of precursor cell death rather than the cell cycle.