Transport of a graphene nanosheet sandwiched inside cell membranes
Transport of a graphene nanosheet sandwiched inside cell membranes
复制标题
夹在细胞膜内的石墨烯纳米片的传输
DOI：
10.1126/sciadv.aaw3192
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发表时间：
2019-06-01
期刊：
影响因子：
13.6
通讯作者：
Yan, Li-Tang
中科院分区：
文献类型：
--
作者：
Chen, Pengyu;Yue, Hua;Yan, Li-Tang
纳米粒子在生物-纳米界面的传输对于许多细胞反应和生物医学应用是必不可少的。二维纳米材料，如石墨烯和过渡金属二硫属化物，如何沿细胞膜沿着扩散是未知的，然而，提出了一个紧迫和重要的问题，以促进其在生物医学领域的应用。在这里，我们证明了夹在细胞膜内的氧化石墨烯（石墨烯）的运输从布朗到Lévy甚至是定向动力学。具体而言，实验证据表明在不同的细胞中夹有石墨烯细胞膜上层结构。结合模拟和分析确定了一个三明治GO诱导孔细胞膜小叶，跨越不稳定，亚稳态和稳定状态。一个分析模型，合理化的制度，这些膜孔状态适合模拟定量，导致在机械的解释出现的Lévy和定向动力学。最后，我们证明了三明治的适用性，在提高效率的膜特异性药物输送。我们的研究结果为编程二维纳米材料的膜内运输以实现有利的生物医学应用提供了方法。
The transport of nanoparticles at bio-nano interfaces is essential for many cellular responses and biomedical applications. How two-dimensional nanomaterials, such as graphene and transition-metal dichalcogenides, diffuse along the cell membrane is, however, unknown, posing an urgent and important issue to promote their applications in the biomedical area. Here, we show that the transport of graphene oxides (GOs) sandwiched inside cell membranes varies from Brownian to Lévy and even directional dynamics. Specifically, experiments evidence sandwiched graphene–cell membrane superstructures in different cells. Combined simulations and analysis identify a sandwiched GO–induced pore in cell membrane leaflets, spanning unstable, metastable, and stable states. An analytical model that rationalizes the regimes of these membrane-pore states fits simulations quantitatively, resulting in a mechanistic interpretation of the emergence of Lévy and directional dynamics. We finally demonstrate the applicability of sandwiched GOs in enhanced efficiency of membrane-specific drug delivery. Our findings inform approaches to programming intramembrane transport of two-dimensional nanomaterials toward advantageous biomedical applications.