Early detection of probable idiopathic Parkinson's disease: I. Development of a diagnostic test battery
Early detection of probable idiopathic Parkinson's disease: I. Development of a diagnostic test battery
复制标题
DOI：
10.1002/1531-8257(200005)15:3
复制
发表时间：
2000-05-01
影响因子：
8.6
通讯作者：
Lyons, K
中科院分区：
文献类型：
--
作者：
Montgomery, EB;Koller, WC;Lyons, K
我们开发了一个测试电池作为一个廉价的和客观的援助，早期诊断特发性帕金森病（iPD）及其鉴别诊断。成套测试包括运动功能、嗅觉和情绪测试。在运动任务中，腕关节屈伸任务，以不同的目标，运动速度被记录。嗅觉用宾夕法尼亚大学嗅觉鉴定测试进行测试。情绪与贝克抑郁量表进行了评估。根据19例正常对照受试者和18例早期、轻度、可能iPD患者的结果建立了初始回归模型。前瞻性应用于122名正常对照受试者和103名患者的独立验证集，特异性率为88%，灵敏度为69%，受试者操作特征曲线下面积为0.87。
We developed a test battery as an inexpensive and objective aid for the early diagnosis of idiopathic Parkinson's disease (iPD) and its differential diagnoses. The test battery incorporates tests of motor function, olfaction, and mood. In the motor task, a wrist flexion-and-extension task to different targets, movement velocities were recorded. Olfaction was tested with the University of Pennsylvania Smell Identification Test. Mood was assessed with the Beck Depression Inventory. An initial regression model was developed from the results of 19 normal control subjects and 18 patients with early, mild, probable iPD. Prospective application to an independent validation set of 122 normal control subjects and 103 patients resulted in an 88% specificity rate and 69% sensitivity rate, with an area under the Receiver Operator Characteristic curve of 0.87.