Synchronized retinal oscillations encode essential information for escape behavior in frogs
Synchronized retinal oscillations encode essential information for escape behavior in frogs
复制标题
DOI：
10.1038/nn1497
复制
发表时间：
2005-08-01
影响因子：
25
通讯作者：
Tachibana, M
中科院分区：
文献类型：
--
作者：
Ishikane, H;Gangi, M;Tachibana, M
视觉神经元之间产生同步振荡活动的方式取决于视觉刺激的某些关键特征。尽管这种活动对于知觉整合可能很重要，但其功能意义尚未得到解释。在这里，我们发现一类青蛙视网膜神经节细胞（调光探测器）的同步振荡活动与众所周知的逃避反应之间存在非常强的相关性，如行为测试和孤立视网膜的多电极记录所示。眼内注射 GABA(A) 受体和 GABA(C) 受体拮抗剂分别可抑制和增强由扩大的黑斑引起的逃逸行为。逃避行为的变化与拮抗剂引起的同步振荡活动的变化相关，但与调光探测器放电率的变化无关。除了调光检测器之外，这些拮抗剂不影响视网膜神经节细胞中扩大的黑点诱导的反应。因此，青蛙视网膜的同步振荡很可能编码与逃脱相关的信息。
Synchronized oscillatory activity is generated among visual neurons in a manner that depends on certain key features of visual stimulation. Although this activity may be important for perceptual integration, its functional significance has yet to be explained. Here we find a very strong correlation between synchronized oscillatory activity in a class of frog retinal ganglion cells ( dimming detectors) and a well-known escape response, as shown by behavioral tests and multi-electrode recordings from isolated retinas. Escape behavior elicited by an expanding dark spot was suppressed and potentiated by intraocular injection of GABA(A) receptor and GABA(C) receptor antagonists, respectively. Changes in escape behavior correlated with antagonist-evoked changes in synchronized oscillatory activity but not with changes in the discharge rate of dimming detectors. These antagonists did not affect the expanding dark spot - induced responses in retinal ganglion cells other than dimming detectors. Thus, synchronized oscillations in the retina are likely to encode escape-related information in frogs.