Reductive Difunctionalization of Aryl Alkenes with Sodium Metal and Reduction-Resistant Alkoxy-Substituted Electrophiles
Reductive Difunctionalization of Aryl Alkenes with Sodium Metal and Reduction-Resistant Alkoxy-Substituted Electrophiles
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DOI：
10.1021/acs.orglett.0c00490
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发表时间：
2020-03-20
期刊：
影响因子：
5.2
通讯作者：
Yorimitsu, Hideki
中科院分区：
文献类型：
--
作者：
Fukazawa, Mizuki;Takahashi, Fumiya;Yorimitsu, Hideki
利用烷氧基取代的抗还原亲电试剂，发展了一种碱金属促进的烯烃还原双官能化的通用方法。利用三甲氧基硼烷和应变环醚如环氧乙烷和氧杂环丁烷可以合成一系列1，2-二硼化和1，2-二碳官能化产物。此外，不对称的碳或硫硼已完成通过顺序处理与三甲氧基硼烷和碳或硫亲电试剂。
A general method for alkali-metal-promoted reductive difunctionalization of alkenes has been developed by means of reduction-resistant alkoxy-substituted electrophiles. A series of 1,2-diboration and 1,2-dicarbofunctionalization products can be synthesized by employing trimethoxyborane and strained cyclic ethers such as oxirane and oxetane. In addition, unsymmetrical carbo- or thioborations have been accomplished via sequential treatment with trimethoxyborane and carbon or sulfur electrophiles.