Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response.
Distinct, specific IL-17- and IL-22-producing CD4+ T cell subsets contribute to the human anti-mycobacterial immune response.
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独特的，特定的IL-17-和IL-22产生的CD4+ T细胞子集有助于人类抗细菌免疫反应。
DOI：
10.4049/jimmunol.180.3.1962
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发表时间：
2008-02-01
影响因子：
4.4
通讯作者：
Hanekom, Willem A.
中科院分区：
文献类型：
--
作者：
Scriba, Thomas J.;Kalsdorf, Barbara;Abrahams, Deborah-Ann;Isaacs, Fatima;Hofmeister, Jessica;Black, Gillian;Hassan, Hisham Y.;Wilkinson, Robert J.;Walzl, Gerhard;Gelderbloem, Sebastian J.;Mahomed, Hassan;Hussey, Gregory D.;Hanekom, Willem A.
我们研究了人类分枝杆菌感染是否诱导促炎性T细胞细胞因子白细胞介素-17（IL-17）和IL-22。值得注意的是，在健康的、暴露于分枝杆菌的成年人的外周血中，>20%的特异性产生亮氨酸的CD 4 + T细胞表达IL-17或IL-22。产生IL-17和IL-22的特异性CD 4 + T细胞彼此不同，并且与产生Th 1型白细胞介素的细胞不同。这些细胞具有长寿的中央记忆细胞的表型特征。与健康对照组相比，结核病患者外周血中这些细胞的频率降低，而支气管肺泡灌洗液（BALF）中含有更高水平的IL-22蛋白。在该液体中未检测到IL-17，这可能是由于Th 1细胞因子的抑制，因为PBMC IL-17的产生在体外被IFN-γ抑制。然而，Th 1细胞因子在体外对IL-22的产生没有影响。我们的研究结果表明，抗分枝杆菌免疫反应的规模和复杂性历来被低估。产生IL-17和IL-22的CD 4 + T细胞可能在人类对分枝杆菌的免疫应答中发挥重要作用。
We investigated whether the pro-inflammatory T cell cytokines interleukin-17 (IL-17) and IL-22 are induced by human mycobacterial infection. Remarkably, >20% of specific cytokine-producing CD4+ T cells in peripheral blood of healthy, mycobacteria-exposed adults expressed IL-17 or IL-22. Specific IL-17 and IL-22 producing CD4+ T cells were distinct from each other and from Th1 cytokine-producing cells. These cells had phenotypic characteristics of long-lived central memory cells. In patients with tuberculosis disease, peripheral blood frequencies of these cells were reduced, while bronchoalveolar lavage fluid (BALF) contained higher levels of IL-22 protein, compared with healthy controls. IL-17 was not detected in this fluid, which may be due to suppression by Th1 cytokines, as PBMC IL-17 production was inhibited by IFN-γ in vitro. However, Th1 cytokines had no effect on IL-22 production in vitro. Our results imply that the magnitude and complexity of the anti-mycobacterial immune response have historically been underestimated. IL-17 and IL-22-producing CD4+ T cells may play important roles in the human immune response to mycobacteria.
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DOI：
10.1084/jem.20070663
发表时间：
2007-08-06
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Annunziato F;Cosmi L;Santarlasci V;Maggi L;Liotta F;Mazzinghi B;Parente E;Filì L;Ferri S;Frosali F;Giudici F;Romagnani P;Parronchi P;Tonelli F;Maggi E;Romagnani S
通讯作者：
Romagnani S
影响因子：
30.5
作者：
Acosta-Rodriguez, Eva V.;Napolitani, Giorgio;Sallusto, Federica
通讯作者：
Sallusto, Federica
影响因子：
64.8
作者：
Bettelli, E;Carrier, YJ;Kuchroo, VK
通讯作者：
Kuchroo, VK
DOI：
10.1084/jem.175.4.1111
发表时间：
1992-04-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Chan J;Xing Y;Magliozzo RS;Bloom BR
通讯作者：
Bloom BR
影响因子：
4.4
作者：
Cruz, Andrea;Khader, Shabaana A.;Castro, Antonio G.
通讯作者：
Castro, Antonio G.