The effect of exogenous GM1 ganglioside on kindled-amygdaloid seizures
The effect of exogenous GM1 ganglioside on kindled-amygdaloid seizures
复制标题
外源性 GM1 神经节苷脂对点燃杏仁样癫痫发作的影响
DOI：
10.1016/0028-3908(87)90217-6
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发表时间：
1987
影响因子：
4.7
通讯作者：
W. Walby
中科院分区：
文献类型：
--
作者：
T. Albertson;W. Walby
腹腔注射 12 日剂量 30mg/kg GM1 神经节苷脂的效果研究了大鼠中点燃杏仁核癫痫发作的获得性。在采集阶段没有注意到点燃率或诱发癫痫发作的表达发生变化。对额外的完全杏仁核点燃的大鼠进行的进一步研究未能显示单次 30-60mg/kg 腹膜内注射后阈上或阈值的显着改变引起癫痫发作。 GM1神经节苷脂的剂量。尽管之前的研究表明 GM1 神经节苷脂抗体具有惊厥作用，但在本研究中，使用一组点燃的杏仁核苷癫痫试验，在大鼠中使用外源性 GM1 神经节苷脂，没有显示出抗惊厥活性。
The effects of 12 daily doses of 30mg/kg GM1ganglioside i.p. on the acquisition of kindled-amygdaloid seizures in the rat was studied. No modification in the rate of kindling or the expression of the elicited seizures was noted during the acquisition phase. Further studies with additional fully amygdaloid kindled rats failed to show significant modification of suprathreshold or threshold elicited seizures after single 30–60mg/kg i.p. doses of GM1ganglioside. Despite previous studies which have shown antibodies to GM1ganglioside to be convulsive, no anticonvul sant activity was demonstrated in this study with exogenous GM1ganglioside using a battery of kindled-amygdaloid seizure tests in the rat.