The safety of neoadjuvant chemotherapy combined with non-tube nofasting fast-track surgery for esophageal carcinoma.
The safety of neoadjuvant chemotherapy combined with non-tube nofasting fast-track surgery for esophageal carcinoma.
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DOI：
10.3389/fonc.2022.906439
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发表时间：
2022
影响因子：
4.7
通讯作者：
Xing, Wenqun
中科院分区：
文献类型：
--
作者：
Zheng, Yan;Hao, Wentao;Li, Yin;Liu, Xianben;Wang, Zongfei;Sun, Haibo;Liu, Shilei;Xing, Wenqun
关键词：
我们的无管免禁食（早期经口喂养和无鼻胃管）快速康复手术（FTS）与新辅助化疗联合用于McKeown微创食管切除术是安全有效的。此外，两组在恢复时间、出院日、及早恢复经口喂养方面也相似。评价早期经口喂养（EOF）联合食管癌新辅助化疗（NAC）的安全性。我们的无管免禁食（早期经口喂养且无鼻胃管）快速通道手术（FTS）对于初次手术的食管癌患者安全有效。我们回顾性评估了连续接受非管禁食和 McKeown 微创 (MIE) 治疗的患者。他们被分为两组：一组接受 NAC，另一组接受初次手术。评估术后并发症、术后CRG并发症、手术时间、手术出血和住院时间。 2014年1月至2017年12月期间，连续182名患者在非管免禁食快速通道手术计划下接受了两野全淋巴结切除术的MIE。共有 137 名患者接受了 NAC，245 名患者接受了初次手术。使用倾向评分匹配将 NAC 患者与每组 62 名匹配患者进行比较。 NAC 组的总并发症数量与初次手术组相似（初次手术组为 32.26%，NAC 组为 25.81%；p=0.429），并且术后中位住院时间相同（8 天，p=0.723）。 McKeown MIE 后，接受 NAC 联合“非管免禁食”FTS 的患者术后并发症发生率与未接受 NAC 的患者相似。此外，两组在恢复时间、出院日、及早恢复经口喂养方面也相似。
Our non-tube no fasting (early oral feeding and no nasogastric tube) fast-track surgery (FTS) was safe and effective to combine with neoadjuvant chemotherapy for McKeown minimally invasive esophagectomy. In addition, the two groups were similar in terms of the recovery time, hospital discharge day, and early resumption of oral feeding. To evaluate the safety of early oral feeding (EOF) combined with neoadjuvant chemotherapy (NAC) of esophagectomy. Our non-tube no fasting (early oral feeding and no nasogastric tube) fast-track surgery (FTS) was safe and effective for primary surgery esophageal cancer patients. We retrospectively evaluated consecutive patients who underwent non-tube no fasting and McKeown minimally invasive (MIE). They were divided into two groups: one received NAC, and the other received primary surgery. Complications after the operation, postoperative CRG complications, operative time, operative bleeding, and length of stay were evaluated. Between 01/2014 and 12/2017, there hundred and eighty two consecutive patients underwent MIE with total two-field lymphadenectomy under the non-tube no fasting fast-track surgery program. A total of 137 patients received NAC, and 245 accepted primary surgery. Propensity score matching was used to compare NAC patients with 62 matched patients from each group. The NAC group had a similar number of total complications as the primary surgery group (32.26% in the primary surgery group vs. 25.81% in the NAC group; p=0.429) and had the same median postoperative hospitalization duration (8 days, p=0.723). After McKeown MIE, the patients receiving NAC combined with “non-tube no fasting” FTS had a similar incidence of postoperative complications outcomes as those without NAC. In addition, the two groups were similar in terms of the recovery time, hospital discharge day, and early resumption of oral feeding.
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影响因子：
3.9
作者：
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通讯作者：
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