Specific carcinoembryonic antigens of the human digestive system.
Specific carcinoembryonic antigens of the human digestive system.
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DOI：
10.1084/jem.122.3.467
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发表时间：
1965-09-01
期刊：
影响因子：
--
通讯作者：
Freedman SO
中科院分区：
文献类型：
--
作者：
Gold P;Freedman SO
在琼脂凝胶中通过免疫扩散技术研究了各种各样的成人和胎儿组织，以确定它们是否含有先前在共离子癌中发现的肿瘤特异性抗原。在成人组织中，证明了相同的抗原存在于胃肠道和胰腺的内胚层来源的上皮的恶性肿瘤的所有测试样本中，但不存在于所有其他测试的成人组织中。因此，共同的抗原成分代表人类消化系统的系统特异性癌抗原。系统特异性癌抗原以前未在人类中得到证实。胎儿组织实验表明，相同的抗原也存在于胎儿肠道，肝脏和胰腺之间的妊娠2至6个月。这些成分被命名为人类消化系统的“癌胚”抗原。根据目前的发现和最近关于控制各种类型细胞中遗传潜能表达的工作，可以得出结论，癌胚抗原代表在正常消化系统上皮分化过程中受到抑制的细胞成分，并通过去抑制-去分化过程在相应的恶性细胞中重新出现。
A wide variety of human adult and fetal tissues were studied by immune-diffusion techniques in agar gel to determine whether they contained the tumor-specific antigen(s) previously found in coionic cancers. In the adult tissues it was demonstrated that identical antigens were present in all tested specimens of malignant tumors of the entodermally derived epithelium of the gastrointestinal tract and pancreas, but were absent from all other tested adult tissues. The common antigenic constituents, therefore, represent system-specific cancer antigens of the human digestive system. System-specific cancer antigens have not previously been demonstrated in humans. Experiments with fetal tissues demonstrated that identical antigens were also present in fetal gut, liver, and pancreas between 2 and 6 months of gestation. These components were named "carcinoembryonic" antigens of the human digestive system. On the basis of the present findings and the recent work regarding control of the expression of genetic potentialities in various types of cells, it was concluded that the carcinoembryonic antigens represent cellular constituents which are repressed during the course of differentiation of the normal digestive system epithelium and reappear in the corresponding malignant cells by a process of derepressive-dedifferentiation.