Antibiotics as signalling molecules
Antibiotics as signalling molecules
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DOI：
10.1098/rstb.2007.2044
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发表时间：
2007-07-29
影响因子：
6.3
通讯作者：
Davies, Julian
中科院分区：
文献类型：
--
作者：
Yim, Grace;Wang, Helena Huimi;Davies, Julian
我们提出的论点是，大多数低分子量的有机化合物，由微生物产生和分泌的细胞信号分子在环境中发挥作用。在迄今为止分离的大量化合物中，只有一小部分显示出具有有用的治疗抗生素活性。然而，大多数微生物代谢物在低浓度下调节基因转录，这被认为是化合物在维持环境中微生物群落中的主要作用。因此，微生物代谢物构成了大量细胞信号分子的集合，这些分子调节微生物种群中的基因表达，并可能调节这些种群与周围生物的相互作用。
We present the argument that the majority of low- molecular- weight organic compounds made and secreted by microbes play roles as cell- signalling molecules in the environment. Of the large number of compounds isolated to date, only a small fraction have been shown to possess useful therapeutic antibiotic activity. However, most microbial metabolites modulate gene transcription at low concentrations, and this is proposed to be the primary effect of the compounds in the maintenance of microbial communities in the environment. Thus, microbial metabolites constitute a large collection of cell- signalling molecules that regulate gene expression in microbial populations and possibly the interactions of these populations with the surrounding organisms.