The pachytene checkpoint
The pachytene checkpoint
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DOI：
10.1016/s0168-9525(00)02080-1
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发表时间：
2000-09-01
影响因子：
11.4
通讯作者：
Bailis, JM
中科院分区：
文献类型：
--
作者：
Roeder, GS;Bailis, JM
粗线期检查点阻止未能完成减数分裂重组和染色体联会的细胞中的减数分裂核分裂。这种控制机制防止染色体错误分离，这将导致非整倍体配子的产生。粗线期检查点需要在有丝分裂DNA损伤检查点中起作用的蛋白质的子集。在芽殖酵母中，粗线期检查点还需要减数分裂特异性染色体蛋白，并且出乎意料地，需要集中在核仁中的蛋白。在确定受检查点影响的细胞周期机制的组成部分方面取得了进展。
The pachytene checkpoint prevents meiotic nuclear division in cells that fail to complete meiotic recombination and chromosome synapsis. This control mechanism prevents chromosome missegregation that would lead to the production of aneuploid gametes. The pachytene checkpoint requires a subset of proteins that function in the mitotic DNA damage checkpoint. In budding yeast, the pachytene checkpoint also requires meiosis-specific chromosomal proteins and, unexpectedly, proteins concentrated in the nucleolus. Progress has been made in identifying components of the cell-cycle machinery that are impacted by the checkpoint.