P2X(7) receptor: Death or life?
P2X(7) receptor: Death or life?
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DOI：
10.1007/s11302-005-6322-x
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发表时间：
2005-09
影响因子：
3.5
通讯作者：
Ferrari, Davide
中科院分区：
文献类型：
--
作者：
Adinolfi, Elena;Pizzirani, Cinzia;Idzko, Marco;Panther, Elisabeth;Norgauer, Johannes;Di Virgilio, Francesco;Ferrari, Davide
P2X7 质膜受体是一种有趣的分子，它具有杀死细胞、激活许多反应甚至刺激增殖的能力。在这里，作者概述了 P2X7 介导的反应的多样性和复杂性，并讨论了有关该受体的最新信息。人们特别关注与受体激活以及癌发生中 P2X7 功能的新兴领域相关的细胞凋亡和坏死的早期和晚期迹象。
The P2X7 plasma membrane receptor is an intriguing molecule that is endowed with the ability to kill cells, as well as to activate many responses and even stimulate proliferation. Here, the authors give an overview on the multiplicity and complexity of P2X7-mediated responses, discussing recent information on this receptor. Particular attention has been paid to early and late signs of apoptosis and necrosis linked to activation of the receptor and to the emerging field of P2X7 function in carcinogenesis.