Neutrophil gelatinase-associated lipocalin levels associated with cardiovascular disease in chronic kidney disease patients
Neutrophil gelatinase-associated lipocalin levels associated with cardiovascular disease in chronic kidney disease patients
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DOI：
10.1007/s10157-013-0923-4
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发表时间：
2014-10
影响因子：
2.3
通讯作者：
F. Furuya;H. Shimura;H. Yokomichi;Kazuya Takahashi;Daiichiro Akiyama;Chikako Asakawa;A. Okamura;Ai Motosugi;K. Haraguchi;Z. Yamagata;Tetsuro Kobayashi
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文献类型：
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作者：
F. Furuya;H. Shimura;H. Yokomichi;Kazuya Takahashi;Daiichiro Akiyama;Chikako Asakawa;A. Okamura;Ai Motosugi;K. Haraguchi;Z. Yamagata;Tetsuro Kobayashi
据报道，心血管疾病(CVD)、心力衰竭和中风患者的中性粒细胞明胶酶相关脂钙蛋白(NGAL)水平升高。我们评估了血液透析(HD)患者血清NGAL水平与心血管疾病患病率的关系，阐明了血液透析(HD)患者全身NGAL水平对预后的预测作用。采用Logistic回归分析研究新发心血管事件与NGAL水平及其他危险因素的关系。结果20例患者发生心血管事件。新发CVD的HD患者血清NGAL和脑钠素水平显著高于无新发CVD的HD患者。多因素Logistic回归分析显示，初始血NGAL水平是HD患者发生新发心血管疾病的独立危险因素。多因素Logistic回归分析显示，NGAL水平越高，心血管疾病患病率越高。结论NGAL水平可以用来检测合并或不合并糖尿病的血液透析患者心血管疾病的患病率。
BackgroundElevated levels of neutrophil gelatinase-associated lipocalin (NGAL) have been reported in patients with cardiovascular disease (CVD), heart failure, and stroke. We assessed the relationships between serum levels of NGAL and the prevalence of CVD, and clarified the prognostic usefulness of systemic NGAL levels in hemodialysis (HD) patients.MethodsEighty-eight HD patients were followed up for 1 year. Logistic regression analyses were used to investigate the relationship between de novo CVD status and NGAL levels as well as other risk factors.ResultsDuring follow-up, CVD events occurred in 20 patients. Initial serum levels of NGAL and brain natriuretic peptide of HD patients with de novo CVD were significantly higher than those of HD patients without de novo CVD. Multivariate logistic regression analyses showed that initial serum levels of NGAL were independent risk factors for de novo CVD in HD patients. When patients were classified on the basis of NGAL quartiles, multiple logistic regression analyses demonstrated that the highest quartile of NGAL level showed an increased odds ratio for the prevalence of CVD.ConclusionThese findings suggest that NGAL levels can be used to detect the prevalence of CVD in HD patients with or without diabetes.