Immunogenicity and safety of a live Riemerella anatipestifer vaccine and the contribution of IgA to protective efficacy in Pekin ducks
Immunogenicity and safety of a live Riemerella anatipestifer vaccine and the contribution of IgA to protective efficacy in Pekin ducks
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DOI：
10.1016/j.vetmic.2018.07.010
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发表时间：
2018-08-01
影响因子：
3.3
通讯作者：
Jang, Hyung-Kwan
中科院分区：
文献类型：
--
作者：
Kang, Min;Seo, Hye-Suk;Jang, Hyung-Kwan
鸭疫里默氏杆菌（Riemerella anatipestifer，RA）感染给养鸭业造成了重大的经济损失，本研究开发了一种RA疫苗，用于控制在世界范围内流行的强毒血清1型和2型RA。我们建立了疫苗候选筛选策略，并选择了菌株D15-RDA-92（血清1型）和D14-RDA-8（血清2型）。这些菌株的特征在于：
Riemerella anatipestifer (RA) infections cause major economic losses in the duck industry.In this study, we developed an RA vaccine to control virulent serotype 1 and 2 RA, which predominate in worldwide prevalence. We established a strategy for vaccine candidate screening, and selected strains D15-RDA-92 (serotype 1) and D14-RDA-8 (serotype 2). These strains were characterized by