Gender-specific effect of estrogen receptor-1 gene polymorphisms in coronary artery disease and its angiographic severity in Chinese population
Gender-specific effect of estrogen receptor-1 gene polymorphisms in coronary artery disease and its angiographic severity in Chinese population
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DOI：
10.1016/j.cca.2008.06.004
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发表时间：
2008-09-01
影响因子：
5
通讯作者：
Han, Yunfeng
中科院分区：
文献类型：
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作者：
Xu, Haiying;Hou, Xuwei;Han, Yunfeng
背景资料：雌激素受体-1的常见多态性在冠状动脉疾病（CAD）中的作用，它与血管造影的严重程度提醒冲突的性别和不同races.Methods：210冠状动脉造影定义的中国CAD患者和174名对照组。采用聚合酶链反应（PCR）技术检测DNA多态性。扩增含有PvuII T/C和XbaI A/G位点的区域。结果：冠心病组与对照组PvuII和XbaI基因型及等位基因频率无显著性差异。然而，当按性别分层时，我们注意到PvuII基因型和等位基因频率在CAD和对照组中存在显著差异，但仅在男性组中存在差异，而在女性组中不存在差异。糖尿病、高血压、高LDL水平和PvuII CC基因型是CAD的独立危险因素。PvuII CC与通过病变血管数量测量的CAD血管造影严重程度相关。对于XbaI，没有关联被发现与CAD易感性之前和之后的性别分层。结论：这项研究揭示了性别特异性的影响PvuII多态性在中国CAD科目。PvuII基因多态性仅影响男性CAD易感性PvuII CC是CAD的风险因素，与血管造影CAD严重度相关。(C)2008 Elsevier B. V.保留所有权利。
Background: The role of common polymorphisms of the estrogen receptor-1 in coronary artery disease (CAD) and it association with angiographic severity reminds conflicting in sexes and different races.Methods: Two-hundred ten angiographically defined Chinese CAD patients and 174 control subjects were enrolled. DNA was obtained and the polymorphisms were analyzed by the polymerase chain reaction. The region containing the PvuII T/C and the XbaI A/G sites was amplified. PCR product was cleaved with the restriction endonucleases.Results: No significant differences in PvuII and XbaI genotype and allele frequencies were noted between the CAD and controls. However, when stratified by gender, we noticed the PvuII genotype and allele frequencies were significantly different between CAD and controls, but in male group only, not in female group. Diabetes, hypertension, high LDL levels and the PvuII CC genotype were independent risk factors for CAD. PvuII CC was associated with the angiographic severity of CAD measuring by the number of diseased vessels as well. For XbaI, no association was found with the CAD susceptibility before and after gender stratification.Conclusion: This study revealed a gender-specific effect of PvuII polymorphism in Chinese CAD subjects. PvuII gene polymorphisms affect CAD susceptibility in man only. The PvuII CC is a risk factor for CAD and it is associated with angiographic CAD severity. (C) 2008 Elsevier B.V. All rights reserved.