Brain and cognitive-behavioural development after asphyxia at term birth
Brain and cognitive-behavioural development after asphyxia at term birth
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DOI：
10.1111/j.1467-7687.2006.00499.x
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发表时间：
2006-07-01
影响因子：
3.7
通讯作者：
Mishkin, Mortimer
中科院分区：
文献类型：
--
作者：
de Haan, Michelle;Wyatt, John S.;Mishkin, Mortimer
围产期窒息的发生率约为1- 6%.。可能导致不同的脑损伤模式，尽管这些模式与长期认知行为结果的关系仍在调查中。海马体是一个可能受损的大脑区域（通常不是孤立的），这个受损部位与两种不同的长期结果有关，认知记忆障碍和精神疾病精神分裂症。除了窒息急性发作外，其他因素也可能导致这些特定结果，使预测变得困难。未来的研究，更好地记录长期的认知行为的结果，定量识别脑损伤的模式在发展中，并考虑其他变量，可能会调节窒息对认知和行为功能的影响，将提出预测长期结果和了解其展开的机制的目标。
Perinatal asphyxia occurs in approximately 1-6 per 1000 live full-term births. Different patterns of brain damage can result, though the relation of these patterns to long-term cognitive-behavioural outcome remains under investigation. The hippocampus is one brain region that can be damaged (typically not in isolation), and this site of damage has been implicated in two different long-term outcomes, cognitive memory impairment and the psychiatric disorder schizophrenia. Factors in addition to the acute episode of asphyxia likely contribute to these specific outcomes, making prediction difficult. Future studies that better document long-term cognitive-behavioural outcome, quantitatively identify patterns of brain injury over development and consider additional variables that may modulate the impact of asphyxia on cognitive and behavioural function will forward the goals of predicting long-term outcome and understanding the mechanisms by which it unfolds.