Phosphoinositide 3-kinase signalling pathways.
Phosphoinositide 3-kinase signalling pathways.
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发表时间：
2001-04
影响因子：
4
通讯作者：
D. Cantrell
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作者：
D. Cantrell
磷脂酰肌醇3-激酶(PI3Ks)使肌醇磷脂的肌醇环3‘-OH位置磷酸化，产生三种脂类产物：PtdIns(3)P，PtdIns(3，4)P(2)和PtdIns(3，4，5)P(3)。这些脂类与蛋白质的Pleckstrin同源(PH)结构域结合，控制着一系列不同的信号转导分子的活性和亚细胞定位。三类主要的信号分子受D-3磷酸肌醇与PH结构域的结合调节：Rho家族GTP酶的鸟氨酸核苷酸交换蛋白，B和T淋巴细胞中的TEC家族酪氨酸激酶，如BTK和ITK，以及AGC超家族丝氨酸/苏氨酸蛋白激酶。这些分子被各种细胞外刺激激活，并参与了广泛的细胞过程，包括细胞周期进程、细胞生长、细胞运动、细胞黏附和细胞生存。
Phosphoinositide 3-kinases (PI3Ks) phosphorylate the 3'-OH position of the inositol ring of inositol phospholipids, producing three lipid products: PtdIns(3)P, PtdIns(3,4)P(2) and PtdIns(3,4,5)P(3). These lipids bind to the pleckstrin homology (PH) domains of proteins and control the activity and subcellular localisation of a diverse array of signal transduction molecules. Three major classes of signalling molecule are regulated by binding of D-3 phosphoinositides to PH domains: guanine-nucleotide-exchange proteins for Rho family GTPases, the TEC family tyrosine kinases such as BTK and ITK in B and T lymphocytes, respectively, and the AGC superfamily of serine/threonine protein kinases. These molecules are activated by a variety of extracellular stimuli and have been implicated in a wide range of cellular processes, including cell cycle progression, cell growth, cell motility, cell adhesion and cell survival.