Nucleus accumbens and medial prefrontal cortex dopaminergic response to self-administered cocaine in naive rats.
Nucleus accumbens and medial prefrontal cortex dopaminergic response to self-administered cocaine in naive rats.
复制标题
幼鼠伏隔核和内侧前额叶皮层对自我施用可卡因的多巴胺能反应。
DOI：
10.1016/j.neulet.2003.10.033
复制
发表时间：
2004
影响因子：
2.5
通讯作者：
Duvauchelle,ChristineL
中科院分区：
文献类型：
--
作者：
Ikegami,Aiko;Duvauchelle,ChristineL
Cocaine reinforcement is strongly associated with increased nucleus accumbens dopamine (NAcc DA). The involvement of medial prefrontal cortex (mPFC) DA in cocaine reward is less defined, but substantial evidence indicates that increased mPFC DA may suppress NAcc DA levels. Using in vivo microdialysis, NAcc or mPFC DA was determined in cocaine-naive rats after a self-administered cocaine injection (3.0 mg/kg). Extracellular levels of NAcc DA were dramatically enhanced 10 min post-cocaine injection, but dropped significantly at each subsequent assessment. mPFC DA also increased significantly, but to a lesser extent than observed in the NAcc. Findings of prominent DA increases in both the NAcc and mPFC terminals during the test session indicate that NAcc DA responses do not appear to be inhibited by increased mPFC DA during cocaine self-administration.
