Protocol for a Controlled Experiment to Identify the Causal Role of Acute Alcohol Consumption in Condomless Sex among HIV-Positive MSM: Study Procedures, Ethical Considerations, and Implications for HIV Prevention.
Protocol for a Controlled Experiment to Identify the Causal Role of Acute Alcohol Consumption in Condomless Sex among HIV-Positive MSM: Study Procedures, Ethical Considerations, and Implications for HIV Prevention.
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DOI：
10.1007/s10461-015-1128-5
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发表时间：
2016-01
影响因子：
4.4
通讯作者：
Rehm J
中科院分区：
文献类型：
--
作者：
Shuper PA;Joharchi N;Rehm J
虽然饮酒经常被认为是无安全套性行为和随后的艾滋病毒感染的驱动因素，但这种关系的因果性质仍不清楚，而且人们对酒精对艾滋病毒阳性者的性风险动态的直接与间接影响知之甚少。为了解决这一差距，我们提出了一个正在进行的NIAAA资助的对照实验，其中艾滋病毒阳性的男男性行为者（MSM）的样本进行酒精消费操纵协议（酒精/安慰剂/对照）和性唤起诱导（性唤起/非性唤起），然后报告与HIV血清状态不同的假设性伴侣进行有避孕套和无避孕套的性行为的意图（HIV+/HIV−/HIV状态未知）、安全套使用偏好（使用/不使用/未说明）和身体吸引力（有吸引力/无吸引力）。研究结果将确定酒精对HIV阳性MSM的无安全套性行为意图的影响，以及风险相关的人格特征和酒精相关的期望。详细的实验程序，伦理方面的考虑，以及对艾滋病毒预防的潜在影响进行了讨论。
Although alcohol consumption is frequently perceived as a driver of condomless sex and subsequent HIV acquisition, the causal nature of this relationship remains unclear, and little is known about alcohol’s direct versus indirect impact on the sexual risk dynamics of those who are HIV-positive. To address this gap, we present the protocol for an in-progress NIAAA-funded controlled experiment, wherein a sample of HIV-positive men-who-have-sex-with-men (MSM) undergoes an alcohol consumption manipulation (alcohol/placebo/control) and sexual arousal induction (sexually aroused/non-aroused), and then reports intentions to engage in condom-protected and condomless sexual acts with hypothetical sexual partners differing in HIV serostatus (HIV+/HIV−/HIV status unknown), condom use preference (use/don’t use/not stated), and physical attractiveness (attractive/unattractive). Study outcomes will identify alcohol’s impact on HIV-positive MSM’s condomless sex intentions in the context of experimentally-manipulated factors as well as risk-relevant personality traits and alcohol-related expectancies. Detailed experimental procedures, ethical considerations, and potential implications for HIV prevention are discussed.