Effects of apatite foam combined with platelet-rich plasma on regeneration of bone defects
Effects of apatite foam combined with platelet-rich plasma on regeneration of bone defects
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DOI：
10.4012/dmj.25.591
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发表时间：
2006-09-01
影响因子：
2.5
通讯作者：
Hamakawa, Hiroyuiki
中科院分区：
文献类型：
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作者：
Sugimori, Eiichirou;Shintani, Satoru;Hamakawa, Hiroyuiki
本研究旨在探讨磷灰石泡沫(AF)复合富血小板血浆(PRP)修复骨缺损的效果。用随机分布的有无PRP的房颤组合填充大鼠胫骨的临界大小的缺损区。动物在3周、6周和12周后被处死，并对它们的组织反应进行组织学检查。在3周时，当PRP(20.3+/-4.2%)和AF(21.6+/-2.9%)单独使用时，我们发现骨再生与对照组(21.9+/-3.1%)没有显著差异。相比之下，显著(p
The objective of this study was to investigate the regenerative effects of apatite foam (AF) combined with platelet-rich plasma (PRP) on bone defects. Critical-sized defects in the tibia of rats were filled with randomly distributed combinations of AF with and without PRP. The animals were killed after three, six, and 12 weeks, and their tissue responses were histologically examined. At three weeks, we found no significant differences in bone regeneration against control group (21.9 +/- 3.1%) when PRP (20.3 +/- 4.2%) and AF (21.6 +/- 2.9%) were used independently of each other. In contrast, significantly (p