Clinical profiles and long-term outcomes of patients with pancreatic ductal adenocarcinoma and diabetes mellitus
Clinical profiles and long-term outcomes of patients with pancreatic ductal adenocarcinoma and diabetes mellitus
复制标题
胰腺导管腺癌合并糖尿病患者的临床特征和长期结局
DOI：
10.1002/dmrr.1284
复制
发表时间：
2012-02-01
影响因子：
8
通讯作者：
Li, Zhaoshen
中科院分区：
文献类型：
--
作者：
Ben, Qiwen;Xu, Maojin;Li, Zhaoshen
背景糖尿病（DM）被认为是胰腺导管腺癌（PDAC）的一个可能的危险因素和/或表现。方法收集中国汉族PDAC患者1123例，其中2年内新发糖尿病256例，2年以上长期糖尿病62例。另外466例2型糖尿病患者纳入本研究。结果与单纯2型糖尿病患者相比，PDAC合并新发糖尿病患者发病年龄大，体重指数（BMI）低。在PDAC病例中，新发糖尿病患者与神经浸润、肿瘤分化差和术后生存期短相关。然而，超过一半的这些患者成为血糖正常手术切除tumors.Conclusions后，PDAC患者新发糖尿病的年龄较大，他们有较短的手术后生存。共病糖尿病影响PDAC患者临床特征和结局的潜在机制值得进一步研究。版权所有（C）2011约翰威利父子有限公司
Background Diabetes mellitus (DM) is considered to be a possible risk factor and/or a manifestation of pancreatic ductal adenocarcinoma (PDAC). This study is aimed at analysing the potential association of diabetes mellitus with the development and pathogenic degrees of PDAC and post-surgical survival of Chinese Han PDAC patients.Methods A total of 1123 patients with PDAC were recruited and included 256 patients with diabetes mellitus within 2 years (new-onset) and 62 patients with diabetes mellitus >= 2 years (long-standing). Additional 466 patients with type 2 diabetes mellitus were included in this study. Their clinical characteristics and long-term outcomes were analysed.Results In comparison with patients with type 2 diabetes mellitus alone, PDAC patients with new-onset diabetes mellitus had an older onset age of diabetes mellitus and lower body mass index (BMI). Among PDAC cases, patients with new-onset diabetes mellitus were associated with neural invasion, poor tumour differentiation and shorter post-surgical survival. However, more than half of these patients became euglycemic after surgical resection of tumours.Conclusions PDAC patients developed new-onset diabetes mellitus at an older age, and they had shorter post-surgical survival. The underlying mechanisms by which comorbid diabetesmellitus affect the clinical profiles and outcomes of PDAC patients deserve further researches. Copyright (C) 2011 John Wiley & Sons, Ltd.