Specialized inhibitory synaptic actions between nearby neocortical pyramidal neurons
Specialized inhibitory synaptic actions between nearby neocortical pyramidal neurons
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DOI：
10.1126/science.1135468
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发表时间：
2007-05-04
期刊：
影响因子：
56.9
通讯作者：
Komatsu, Yukio
中科院分区：
文献类型：
--
作者：
Ren, Ming;Yoshimura, Yumiko;Komatsu, Yukio
我们发现，在小鼠视觉皮层，在一个单一的层2/3锥体（兴奋性）神经元产生的动作电位可以可靠地唤起大，恒定的潜伏期抑制性突触后电流在其他附近的锥体细胞。这种作用是由轴突-轴突离子型谷氨酸受体介导的抑制性中间神经元的神经末梢的兴奋介导的，所述中间神经元连接到靶锥体细胞。因此，个别皮质兴奋性神经元可以产生抑制独立于体放电的抑制性中间神经元。
We found that, in the mouse visual cortex, action potentials generated in a single layer-2/3 pyramidal ( excitatory) neuron can reliably evoke large, constant-latency inhibitory postsynaptic currents in other nearby pyramidal cells. This effect is mediated by axo-axonic ionotropic glutamate receptor-mediated excitation of the nerve terminals of inhibitory interneurons, which connect to the target pyramidal cells. Therefore, individual cortical excitatory neurons can generate inhibition independently from the somatic firing of inhibitory interneurons.