Behavioral and psychological symptoms of dementia in untreated Alzheimer's disease patients
Behavioral and psychological symptoms of dementia in untreated Alzheimer's disease patients
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DOI：
10.1111/j.1479-8301.2006.00153.x
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发表时间：
2007-03-01
期刊：
影响因子：
2
通讯作者：
Kamijima, Kunitoshi
中科院分区：
文献类型：
--
作者：
Hamuro, Atsushi;Isono, Hiroshi;Kamijima, Kunitoshi
背景：确定痴呆患者的精神症状和行为障碍的患病率，对于家庭和卫生保健专业人员预测阿尔茨海默病(AD)的进展和认识病情恶化是有用的。本研究旨在探讨痴呆的行为和心理症状(BPSD)是否与AD的严重程度有关。方法：将202例AD患者按功能评分分为3组：轻度组92例，3、4期；中度组80例，5期；重度组30例，6、7期。BPSD的精神症状包括幻觉、妄想、妄想性误认综合征和抑郁情绪，行为障碍包括躯体攻击、游荡、睡眠不良和吞噬亢进。结果：抑郁情绪、躯体攻击和游荡与AD的严重程度有统计学意义。结论：这些结果对照顾者了解AD的预期进展和认识病情恶化具有重要意义。在AD患者的护理中，有必要了解每个BPSD的特点。
Background: To ascertain the prevalence of psychotic symptoms and behavioral disturbances of dementia patients is useful for families and health care professionals in order to anticipate the progression of Alzheimer's disease (AD) and to recognize deterioration. This study aimed to determine whether behavioral and psychological symptoms of dementia (BPSD) are related to severity of untreated AD.Methods: Two hundred and two patients were classified into three groups by Functional Assessment Staging score as follows: mild group (n = 92) was at stages 3 or 4; moderate group (n = 80) was at stage 5; and severe group (n = 30) was at stages 6 or 7. We then compared the prevalence of BPSD among the groups. Psychiatric symptoms of BPSD were defined as including hallucinations, delusions, delusional misidentification syndrome and depressive mood; while behavioral disturbances included physical aggression, wandering, adverse sleep and hyperphagia.Results: In our study, depressive mood, physical aggression and wandering were statistically associated with the severity of AD.Conclusion: These results are meaningful for caregivers in helping them to understand the anticipated progression of AD and to recognize deterioration. In the care of AD patients, it is necessary to be aware of characteristics of each BPSD.