Associations between antioxidant and zinc intake and the 5-year incidence of early age-related maculopathy in the Beaver Dam Eye Study
Associations between antioxidant and zinc intake and the 5-year incidence of early age-related maculopathy in the Beaver Dam Eye Study
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DOI：
10.1093/oxfordjournals.aje.a009625
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发表时间：
1998-07-15
影响因子：
5
通讯作者：
Palta, M
中科院分区：
文献类型：
--
作者：
VandenLangenberg, GM;Mares-Perlman, JA;Palta, M
在威斯康星州比弗达姆参与比弗达姆眼科研究的中老年人群队列中，研究了抗氧化剂和锌与早期年龄相关性黄斑病变（ARM）5年发病率之间的关联。在基线（1988 - 1990年）时使用食物频率问卷收集该时间段以及10年前（1978 - 1980年）的饮食信息，这些信息来自参与本研究人员的50%随机样本。通过对1709名参与5年随访眼科检查人员的立体彩色眼底照片进行盲法分级，评估了较大玻璃膜疣（>125μm）和色素异常等特定病变的发病率以及任何ARM的发病率。在维生素A原类胡萝卜素和膳食维生素E的摄入量与大玻璃膜疣发病率之间，以及锌与色素异常发病率之间，观察到显著但适度的负相关（p < 0.05）。在抗氧化剂或锌的摄入量与总体早期ARM发病率之间未发现显著的负相关。如果以多种病变为特征的ARM涉及许多不同的潜在病理生理过程，那么特定抗氧化剂与不同黄斑病变发病率之间的关联可能具有生物学重要性。然而，由于该队列中晚期ARM发病病例太少，作者无法评估抗氧化剂摄入是否与早期ARM进展为晚期黄斑变性有关。需要临床试验和更长期的前瞻性研究来进一步阐明抗氧化剂和锌对ARM发生和进展的影响。
Associations between antioxidants and zinc and the 5-year incidence of early, age-related maculopathy (ARM) were investigated in a population-based cohort of middle-aged and older adults participating in the Beaver Dam Eye Study in Beaver Dam, Wisconsin. A food-frequency questionnaire was administered at baseline (1988-1990) to collect dietary information for that time period and a period of time 10 years earlier (1978-1980) from a 50 percent random sample of persons participating in this study. The incidence of the specific lesions of larger drusen (>125 mu) and pigmentary abnormalities and the incidence of any ARM were assessed by masked grading of stereoscopic color fundus photographs in 1,709 persons who participated in 5-year follow-up eye examinations. Significant, but modest, inverse associations (p < 0.05) were observed between intakes of pro-vitamin A carotenoids and dietary vitamin E and the incidence of large drusen and between zinc and the incidence of pigmentary abnormalities. No significant inverse associations were found between antioxidant or zinc intake and the incidence of overall early ARM. If ARM, which is characterized by a broad spectrum of lesions, involves a number of different underlying pathophysiologic processes, then associations between specific antioxidants and the incidence of distinct macular lesions may be biologically important. However, because there were too few incident late ARM cases in this cohort, the authors were unable to assess whether antioxidant intake is associated with the progression of early ARM to tale-stage macular degeneration. Clinical trials and longer-term prospective studies are needed to elucidate further the impact of antioxidants and zinc on the development and progression of ARM.