Pregnancy And Neonatal Outcomes Of hMG Stimulation With Or Without Letrozole In Endometrial Preparation For Frozen-Thawed Embryo Transfer In Ovulatory Women: A Large Retrospective Cohort Study
Pregnancy And Neonatal Outcomes Of hMG Stimulation With Or Without Letrozole In Endometrial Preparation For Frozen-Thawed Embryo Transfer In Ovulatory Women: A Large Retrospective Cohort Study
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排卵期女性冻融胚胎移植子宫内膜准备中使用或不使用来曲唑的 hMG 刺激的妊娠和新生儿结局：一项大型回顾性队列研究
DOI：
10.2147/dddt.s212235
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发表时间：
2019-01-01
影响因子：
4.8
通讯作者：
Wang, Yun
中科院分区：
文献类型：
--
作者：
Lin, Jiaying;Wang, Ningling;Wang, Yun
目的：冷冻-解冻胚胎移植可以将IVF或IVF-ICSI处理后的剩余胚胎保存起来，并在随后的周期中移植到更“生理”的环境中。本研究旨在探讨来曲唑或HMG刺激对排卵患者妊娠及新生儿结局的影响。方法：共5901个FET周期，其中来曲唑1569例，HMG 1827例，来曲唑+HMG 2505例。来曲唑组月经周期第3~5天给予来曲唑2.5 mg，连用3d，第10天开始监测卵泡生长，第10天卵泡直径<14 mm，不需其他促卵巢药物。如果卵泡直径是
Objective: Frozen-thawed embryo transfer enables surplus embryos derived from IVF or IVF-ICSI treatment to be stored and transferred in subsequent cycles into a more "physiologic environment". This study aimed to investigate the clinical effect of letrozole use or hMG stimulation on pregnancy and neonatal outcomes in ovulatory patients undergoing FET.Methods: This study includes a total of 5901 FET cycles with letrozole use (n = 1569), HMG (n = 1827) or letrozole + HMG (n = 2505). In the letrozole group, 2.5 mg of letrozole was administered on menstrual cycle day 3 to 5 for 3 days for patients, and then follicle growth was monitored beginning on day 10. If the follicular diameter was >= 14 mm on the 10th day, no other ovarian stimulation drugs were needed. If the follicular diameter was