Human vascular renin-angiotensin system and its functional changes in relation to different sodium intakes
Human vascular renin-angiotensin system and its functional changes in relation to different sodium intakes
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DOI：
10.1161/01.hyp.31.3.836
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发表时间：
1998-03-01
期刊：
影响因子：
8.3
通讯作者：
Serneri, GGN
中科院分区：
文献类型：
--
作者：
Boddi, M;Poggesi, L;Serneri, GGN
越来越多的证据支持在血管系统中存在基于组织的肾素-血管紧张素系统（RAS），但血管RAS的功能能力尚未在人类中进行研究。通过测量内源性血管紧张素（Ang I和Ang II）在两种不同血管床（前臂和腿部）的动-静脉梯度，并结合I-125-Ang I和I-125-Ang II的动力学研究，研究了28名血压正常的健康对照者在正常、低和高钠饮食中血管紧张素在血管组织中的代谢。在正常钠饮食的受试者中，前臂血管组织提取了36+/-6%的I-125- ang I和30+/-5%的I-125- ang II，并添加了14.9+/-5.1 fmol。100毫升(1)。新生产物的min（-1）生成Ang I和6.2+/-2.8 fmol。100毫升(1)。最小（-1）的Ang II到肘前静脉血。I-125- angi通过前臂血管组织的分数转化率约为12%。低钠饮食增加了(P
A growing body of evidence supports the existence of a tissue-based renin-angiotensin system (RAS) in the vasculature, but the functional capacity of vascular RAS was not investigated in humans. In 28 normotensive healthy control subjects, the metabolism of angiotensins through vascular tissue was investigated in normal, low, and high sodium diets by the measurement of arterial-venous gradient of endogenous angiotensin (Ang I and Ang II in two different vascular beds (forearm and leg), combined with the study of I-125-Ang I and I-125-Ang II kinetics. In normal sodium diet subjects, forearm vascular tissue extracted 36+/-6% of I-125-Ang I and 30+/-5% of I-125-Ang II and added 14.9+/-5.1 fmol . 100 mL(-1). min(-1) of de novo formed Ang I and 6.2+/-2.8 fmol . 100 mL(-1). min(-1) of Ang II to antecubital venous blood. Fractional conversion of I-125-Ang I through forearm vascular tissue was about 12%. Low sodium diet increased (P