Dreamlike effects of LSD on waking imagery in humans depend on serotonin 2A receptor activation
Dreamlike effects of LSD on waking imagery in humans depend on serotonin 2A receptor activation
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DOI：
10.1007/s00213-017-4610-0
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发表时间：
2017-07-01
影响因子：
3.4
通讯作者：
Vollenweider, Franz X.
中科院分区：
文献类型：
--
作者：
Kraehenmann, Rainer;Pokorny, Dan;Vollenweider, Franz X.
越来越多的证据表明，混合5-羟色胺和多巴胺受体激动剂麦角酰二乙胺（LSD）诱导类似于做梦的意识状态改变。本研究旨在验证LSD产生梦幻般的清醒意象的假设，这种意象依赖于5-HT 2A受体激活，并与主观药物效应有关。5名健康受试者在三种药物条件下给药后7小时进行录音引导的心理意象任务：安慰剂、LSD（口服100微克）和LSD与5-HT 2A受体拮抗剂酮色林（口服40毫克）。引导心理意象报告的认知奇异性被量化为梦心理状态的标准化正式测量。使用意识状态改变（5D-ASC）问卷评估意识状态，与安慰剂相比，LSD显著增加认知怪异（p < 0.001）。LSD引起的认知怪异感的增加与LSD引起的自我界限和认知控制的丧失呈正相关（p < 0.05）。LSD引起的认知怪异和意识状态变化的增加都被酮色林完全阻断。LSD产生类似于做梦的心理意象，主要是通过激活5-HT 2A受体，并与自我界限和认知控制的丧失有关。未来的精神药理学研究应该评估D2/D1和5-HT 1A受体对认知怪异的不同贡献。
Accumulating evidence indicates that the mixed serotonin and dopamine receptor agonist lysergic acid diethylamide (LSD) induces an altered state of consciousness that resembles dreaming.This study aimed to test the hypotheses that LSD produces dreamlike waking imagery and that this imagery depends on 5-HT2A receptor activation and is related to subjective drug effects.Twenty-five healthy subjects performed an audiorecorded guided mental imagery task 7 h after drug administration during three drug conditions: placebo, LSD (100 mcg orally) and LSD together with the 5-HT2A receptor antagonist ketanserin (40 mg orally). Cognitive bizarreness of guided mental imagery reports was quantified as a standardised formal measure of dream mentation. State of consciousness was evaluated using the Altered State of Consciousness (5D-ASC) questionnaire.LSD, compared with placebo, significantly increased cognitive bizarreness (p < 0.001). The LSD-induced increase in cognitive bizarreness was positively correlated with the LSD-induced loss of self-boundaries and cognitive control (p < 0.05). Both LSD-induced increases in cognitive bizarreness and changes in state of consciousness were fully blocked by ketanserin.LSD produced mental imagery similar to dreaming, primarily via activation of the 5-HT2A receptor and in relation to loss of self-boundaries and cognitive control. Future psychopharmacological studies should assess the differential contribution of the D2/D1 and 5-HT1A receptors to cognitive bizarreness.