T-cell-mediated concomitant immunity to syngeneic tumors. I. Activated macrophages as the expressors of nonspecific immunity to unrelated tumors and bacterial parasites
T-cell-mediated concomitant immunity to syngeneic tumors. I. Activated macrophages as the expressors of nonspecific immunity to unrelated tumors and bacterial parasites
复制标题
T 细胞介导的针对同基因肿瘤的伴随免疫。
DOI：
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发表时间：
1977
影响因子：
15.3
通讯作者：
D. Kirstein
中科院分区：
文献类型：
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作者：
R. North;D. Kirstein
SA1肉瘤的进行性生长显示出导致产生对相同肿瘤的第二植入物生长的伴随抗性状态。伴随免疫小鼠的应答淋巴结显示含有θ阳性T细胞，其可以特异性地中和正常测试受体中肿瘤细胞的生长。然而，伴随的免疫宿主本身能够在有限程度上抑制无关肿瘤的生长。此外，免疫力的产生与巨噬细胞介导的对细菌寄生虫单核细胞增生李斯特菌的非特异性抗性的强大状态的产生有关。得出的结论是，系统性巨噬细胞活化是T细胞介导的对逐渐生长的肿瘤的免疫产生的结果，这不仅使宿主能够抑制不相关肿瘤的生长，而且还保护自身免受微生物感染。这些结果证实了巨噬细胞在防御微生物和肿瘤生长中发挥核心作用的观点。
Progressive growth of the SA1 sarcoma was shown to result in the generation of a state of concomitant resistance to growth of a second implant of the same tumor. The responding lymph nodes of concomitantly immune mice were shown to contain theta-positive T cells that could specifically neutralize the growth of tumor cells in a normal test recipient. Nevertheless, the concomitantly immune host itself was capable to a limited extent of suppressing the growth of unrelated tumors. The generation of immunity, moreover, was associated with the generation of a powerful state of macrophage-mediated, nonspecific resistance to the bacterial parasite, Listeria monocytogenes. It was concluded that systemic macrophage activation was the consequence of the generation of T-cell-mediated immunity to the progressively growing tumor, and that this not only gave the host the capacity to inhibit the growth of unrelated tumors, but also to protect itself against microbial infection. The results gives credence to the view that macrophages play a central role in defense against microbial and neoplastic growth.