Intrinsically photosensitive ganglion cells contribute to plasticity in retinal wave circuits
Intrinsically photosensitive ganglion cells contribute to plasticity in retinal wave circuits
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DOI：
10.1073/pnas.1222150110
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发表时间：
2013-07-16
影响因子：
11.1
通讯作者：
Feller, Marla B.
中科院分区：
文献类型：
--
作者：
Kirkby, Lowry A.;Feller, Marla B.
在发育中的神经系统中，相关的自发活动对产生它的回路中的扰动是稳健的，这表明存在确保其维持的机制。我们在发育中的视网膜中研究了这一现象，在出生后的第一周，介导视网膜波的胆碱能回路被阻断，导致通过一个独特的间隙连接介导的回路产生“恢复”波。与胆碱能波不同，这些恢复的波是由多巴胺能和谷氨酸能信号调节的，并且需要间隙连接蛋白连接蛋白36的存在。此外，与胆碱能波相反，环境光通过激活表达黑视素的内在光敏视网膜神经节细胞来刺激恢复波。内在光敏的视网膜神经节细胞参与了这种波产生电路的重构，这为视网膜电路在发育过程中的可塑性提供了一条以前未知的途径。
Correlated spontaneous activity in the developing nervous system is robust to perturbations in the circuits that generate it, suggesting that mechanisms exist to ensure its maintenance. We examine this phenomenon in the developing retina, where blockade of cholinergic circuits that mediate retinal waves during the first postnatal week leads to the generation of "recovered" waves through a distinct, gap junction-mediated circuit. Unlike cholinergic waves, these recovered waves were modulated by dopaminergic and glutamatergic signaling, and required the presence of the gap junction protein connexin 36. Moreover, in contrast to cholinergic waves, recovered waves were stimulated by ambient light via activation of melanopsin-expressing intrinsically photosensitive retinal ganglion cells. The involvement of intrinsically photosensitive retinal ganglion cells in this reconfiguration of wave-generating circuits offers an avenue of retinal circuit plasticity during development that was previously unknown.