Application of immunotherapy in pediatric leukemia.
Application of immunotherapy in pediatric leukemia.
复制标题
免疫治疗在小儿白血病中的应用。
DOI：
10.1007/s11899-009-0022-5
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发表时间：
2009
影响因子：
2.9
通讯作者：
Wayne,AlanS
中科院分区：
文献类型：
--
作者：
Wayne,AlanS
尽管儿科白血病的治愈性治疗取得了很大进展，但目前的治疗方法与多种毒性相关，复发后的预后受到保护。需要新的方法来克服对标准治疗的抗性并减少不良反应。异基因干细胞移植的疗效和移植物抗白血病效应的证明表明，基于免疫的疗法可以有效治疗儿童白血病。最近开始努力将新的免疫治疗方法应用于儿科白血病的治疗。最佳的试剂、方法和方案尚未完全确定。正在进行的临床试验在这方面提供了希望。
Despite great progress in the curative treatment of leukemia in pediatrics, current therapies are associated with multiple toxicities and the prognosis after relapse is guarded. Novel approaches are needed to overcome resistance to standard therapy and decrease adverse effects. The efficacy of allogeneic stem cell transplantation and the demonstration of a graft-versus-leukemia effect suggest that immune-based therapies can be effective in the treatment of childhood leukemia. Efforts to apply new immunotherapy approaches to the treatment of leukemia in pediatrics have recently begun. The optimal reagents, methods, and regimens have yet to be fully defined. Ongoing clinical trials offer promise in that regard.