An update on the role of tumor necrosis factor alpha stimulating gene-6 in inflammatory diseases
An update on the role of tumor necrosis factor alpha stimulating gene-6 in inflammatory diseases
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DOI：
10.1016/j.molimm.2022.11.008
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发表时间：
2022-11-12
影响因子：
3.6
通讯作者：
Ma, Yuanfang
中科院分区：
文献类型：
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作者：
Li, Ruomei;Ji, Chengjie;Ma, Yuanfang
目前，炎症性疾病的发生、发展与多种细胞因子含量和功能的异常变化密切相关。同时，靶向相关细胞因子防治疾病也取得了良好的效果。因此，探讨各种细胞因子在炎症性疾病中的作用是非常重要的。肿瘤坏死因子α刺激基因-6（TSG-6）作为一种炎症相关蛋白，越来越受到人们的关注。在疾病的过程中，它就像一把双刃剑，表现出不同的反应。它在某些组织中组成型表达，具有高代谢活性和屏障保护作用。其功能的多样性取决于TSG-6与多种配体结合，包括基质分子、自身免疫调节因子和生长因子，参与细胞外基质重塑和调节蛋白酶网络。本文综述了TSG-6的结构、生物学功能及其在炎症性疾病中的研究进展，以期为今后的药物开发提供参考。
At present, the occurrence and development of inflammatory diseases are closely related to the abnormal changes of the content and function of many cytokines. At the same time, targeting related cytokines to prevent and treat diseases has also achieved good results. Therefore, it is very important to explore the role of various cytokines in inflammatory diseases. As an inflammation related protein, Tumor necrosis factor alpha stimulating gene-6 (TSG-6) has attracted more and more attention. In the process of disease, it's like a double-edged sword, showing different responses. It is constitutively expressed in some tissues with high metabolic activity and barrier protection. The diversity of its functions depends on the binding of TSG-6 with a variety of ligands, including matrix molecules, autoimmune regulatory factors and growth factors, participating in extracellular matrix remodeling and regulating protease network. This paper reviews the structure, biological function and research progress of TSG-6 in inflammatory diseases, in order to provide reference for drug development in the future.