MOLECULAR CHARACTERIZATION OF THE RETINOBLASTOMA SUSCEPTIBILITY GENE
MOLECULAR CHARACTERIZATION OF THE RETINOBLASTOMA SUSCEPTIBILITY GENE
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DOI：
10.1016/0304-419x(93)90021-4
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发表时间：
1993-05-25
期刊：
影响因子：
--
通讯作者：
LEE, WH
中科院分区：
文献类型：
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作者：
GOODRICH, DW;LEE, WH
尽管人们非常重视促癌基因的研究，但长期以来人们一直怀疑抑癌基因的存在[53, 78,126]。与癌基因不同，这些“癌抑制”基因通过突变失活将有助于肿瘤的形成。在含有特定肿瘤抑制基因的两个拷贝的正常二倍体细胞中，需要两次突变才能使其完全失活并释放其对细胞生长的限制。
Although great emphasis has been placed on the study of tumor-promoting oncogenes, the existence of tumor suppressing genes has long been suspected [53, 78,126]. In distinction to oncogenes, the inactivation of these'cancer suppressor'genes by mutation would contribute to tumor formation. In a normal diploid cell containing two copies of a particular tumor suppressor gene, two mutations would be required to completely inactivate it and release its constraint on cell growth.