GDF-15 is associated with thrombus burden in patients with deep venous thrombosis
GDF-15 is associated with thrombus burden in patients with deep venous thrombosis
复制标题
GDF-15 与深静脉血栓形成患者的血栓负荷相关
DOI：
10.1016/j.thromres.2020.01.022
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发表时间：
2020-03-01
影响因子：
7.5
通讯作者：
Yu, Miao
中科院分区：
文献类型：
--
作者：
Liang, Wei;Wei, Fen;Yu, Miao
前言：生长分化因子-15（GDF-15）已被确定为心血管疾病和急性肺栓塞的预测因子。然而，GDF-15与深静脉血栓形成（DVT）的关系仍不清楚。本研究旨在探讨DVT患者血浆GDF-15水平及其与血栓负荷的关系，材料与方法：选取72例初诊DVT患者和30例健康志愿者，检测血浆GDF-15水平。为了探讨GDF-15与血栓严重程度的关系，我们分析了DVT患者的血栓负荷及其与肺栓塞的关系。结果：DVT患者血浆GDF-15水平明显高于健康对照组（1448.78 ± 61.98 pg/ml VS 805.70 ± 112.95 pg/ml，P < 0.01），而对照组血浆GDF-15水平明显低于DVT患者（1448.78 ± 61.98 pg/ml VS 805.70 ± 112.95 pg/ml，P < 0.01）。
Introduction: Growth differentiation factor-15 (GDF-15) has been identified as a predictor in cardiovascular diseases and acute pulmonary embolism. However, the association of GDF-15 and deep venous thrombosis (DVT) remains unclear. This study aimed to investigate levels of GDF-15 in patients with DVT, and determine its association with the thrombus burden.Materials and methods: 72 newly diagnosed DVT patients and 30 healthy volunteers were enrolled, and the levels of plasma GDF-15 were detected. To explore the relationship between GDF-15 and thrombus severity, we analyzed the thrombus burden and the association with pulmonary embolism of DVT patients. In vitro, the effect of GDF-15 on platelet aggregation and thrombin/antithrombin activity were investigated.Results: We found that the mean levels of plasma GDF-15 in DVT patients were significantly higher than those in healthy controls (1448.78 +/- 61.98 pg/ml VS 805.70 +/- 112.95 pg/ml, P