The InterPro Database, 2003 brings increased coverage and new features
The InterPro Database, 2003 brings increased coverage and new features
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DOI：
10.1093/nar/gkg046
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发表时间：
2003-01-01
影响因子：
14.9
通讯作者：
Zdobnov, EM
中科院分区：
文献类型：
--
作者：
Mulder, NJ;Apweiler, R;Zdobnov, EM
Interpro是一种蛋白质家族，域和功能部位的综合文档资源，是在1999年创建的，是将主要蛋白质签名数据库合并为一个综合资源的平均值。 Prosite，PFAM，Prints，Prodom，Smart和Tigrfams已手动集成和策划，并在Interpro中用于基于文本和序列的搜索。结果以单一格式提供，可以合理地通过单独搜索成员数据库来获得结果。 Interpro的最新版本包含5629个条目，描述了4280个家庭，1239个域，95个重复和15个翻译后修道院。目前，Interpro中的联合签名覆盖了瑞士 - 普罗特和Trembl中所有蛋白质的74％以上，自Interpro的成立以来，近15％增加了近15％。数据库的新功能包括改进的搜索功能和增强的图形用户界面以可视化数据。该数据库可通过Web服务器（http://www.ebi.ac.uk/interpro）和匿名FTP（ftp://ftp.ebi.ac.ac.ac.uk/pub/databases/interpro）获得。
InterPro, an integrated documentation resource of protein families, domains and functional sites, was created in 1999 as a mean of amalgamating the major protein signature database into one comprehensive resource. PROSITE, Pfam, PRINTS, ProDom, SMART and TIGRFAMs have been manually integrated and curated and are available in InterPro for text- and sequence-based searching. The results are provided in a single format that rationalises the result that would be obtained by searching the member databases individually. The latest release of InterPro contains 5629 entries describing 4280 families, 1239 domains, 95 repeats and 15 post-translational modi cations. Currently, the combined signatures in InterPro cover more than 74% of all proteins in SWISS-PROT and TrEMBL, an increase of nearly 15% since the inception of InterPro. New features of the database include improved searching capabilities and enhanced graphical user interfaces for visualisation of the data. The database is available via a webserver (http://www.ebi.ac.uk/interpro) and anonymous FTP (ftp://ftp.ebi.ac.uk/pub/databases/interpro).