HIGHER LEVELS OF NICOTINE IN ARTERIAL THAN IN VENOUS-BLOOD AFTER CIGARETTE-SMOKING
HIGHER LEVELS OF NICOTINE IN ARTERIAL THAN IN VENOUS-BLOOD AFTER CIGARETTE-SMOKING
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DOI：
10.1016/0376-8716(93)90030-t
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发表时间：
1993-06-01
影响因子：
4.2
通讯作者：
LONDON, ED
中科院分区：
文献类型：
--
作者：
HENNINGFIELD, JE;STAPLETON, JM;LONDON, ED
我们检查了人类受试者动脉和静脉中尼古丁浓度的差异。吸烟后不久，动脉血浆中的尼古丁水平是静脉血浆中的两倍多。动脉尼古丁水平上升的时间过程和动静脉差异的大小在受试者之间有很大差异。对一些受试者来说，吸一支烟后动脉尼古丁浓度与吸20支烟后通常观察到的静脉尼古丁浓度相似，几乎是静脉尼古丁浓度的10倍。我们的发现对理解吸烟形式的药物的高度成瘾性和心血管毒性具有启示意义。
We examined differences between arterial and venous concentrations of nicotine in human subjects. Shortly after smoking a cigarette, levels of nicotine in arterial plasma were more than double those in venous plasma. The time course of the rise in arterial nicotine levels and the magnitude of the arteriovenous difference varied considerably among subjects. For some subjects, arterial nicotine concentrations after one cigarette were similar to venous concentrations typically observed after 20 cigarettes and were nearly 10 times greater than venous concentrations. Our findings have implications for understanding the high degree of addictiveness and cardiovascular toxicity of smoked forms of drugs.