Neuropsychological assessment of older adults with Down's syndrome: An epidemiological study using the Cambridge Cognitive Examination (CAMCOG)
Neuropsychological assessment of older adults with Down's syndrome: An epidemiological study using the Cambridge Cognitive Examination (CAMCOG)
复制标题
DOI：
10.1348/014466599162719
复制
发表时间：
1999-06-01
影响因子：
3.1
通讯作者：
Watson, P
中科院分区：
文献类型：
--
作者：
Hon, J;Huppert, FA;Watson, P
目标。剑桥认知考试(CAMCOG)是为普通老年人群设计的，以评估痴呆症特有的认知障碍。CAMCOG给出了总分和七个分量表的单独分数。在这项研究中，评估了CAMCOG对患痴呆症风险年龄的唐氏综合症(DS)老年人的适用性。使用CAMCOG确定和评估了居住在单一卫生当局集水区的30岁及以上(30-65岁)DS患者的几乎全部人口样本。未经选择的样本的使用确保了这一评估工具的价值可以在DS患者的所有残疾水平上确定。使用30岁的较低年龄限制，因为从这个年龄段开始出现明显的阿尔茨海默病样神经病变，阿尔茨海默病的患病率开始增加。CAMCOG是在熟悉的环境下与其他神经心理测试一起进行的。调查不同性别、年龄的被试者的性别、年龄差异以及被试者的特征。在77名年龄在30岁或以上的DS患者中，74人同意支付部分费用。CAMCOG的分数分布均匀，只有8名参与者(11%)在测试中得了0分。这与迷你精神状态考试的表现形成了鲜明对比，后者的分数范围较窄，得分为0的百分比较高。年轻(30-44岁)和老年(45岁以上)受试者在CAMCOG总分和7个CAMCOG分量表中的6个分量表上的认知表现有显著差异。CAMCOG，经过微小的修改，是一种有用的测试，可以评估那些已知随着痴呆症而下降的认知功能区域。除了那些先前存在严重学习障碍、严重感觉障碍和/或已经患有痴呆症的人，患有DS的人能够在测试的底线上获得高于底线的分数。
Objectives. The Cambridge Cognitive Examination (CAMCOG) was designed for the general elderly population to assess cognitive impairments characteristic of dementia. CAMCOG yields a total score as well as separate scores on seven subscales. In this study the suitability of the CAMCOG for older adults with Down's Syndrome (DS) at the age of risk for dementia was assessed.Design. A near total population sample of people with DS aged 30 years and over (range 30-65 years) living in a single Health Authority catchment area was identified and assessed using the CAMCOG. The use of an unselected sample ensured that the value of this assessment instrument could be established across all levels of disability in those with DS. A lower age limit of 30 years was used, as from this age significant Alzheimer-like neuropathology is present and prevalence rates of Alzheimer's disease begin to increase.Methods. The CAMCOG was administered in a familiar setting together with other neuropsychological tests. Gender and age differences and the characteristics of those at the floor of the test were investigated.Results. Of the 77 people with DS aged 30 years or older, 74 agreed to rake part. Scores on the CAMCOG were well distributed, with only eight participants (11%) scoring 0 on the test. This contrasted favourably with performance on the Mini-Mental State Examination where there was a narrower range of scores and a higher percentage scoring 0. There was a significant difference in cognitive performance between younger (30-44 years) and older (45+ years) participants on the total CAMCOG score and on six out of the seven CAMCOG subscales.Conclusions. The CAMCOG, with minor modifications, is a useful test to assess those areas of cognitive function known to decline with dementia. Apart from those with pre-existing severe learning disability, severe sensory impairments and/or already advanced dementia, people with DS were able to score above the floor of the test.