Foods and Nutrients in Relation to Bladder Cancer Risk: A Case-Control Study in Aichi Prefecture, Central Japan
Foods and Nutrients in Relation to Bladder Cancer Risk: A Case-Control Study in Aichi Prefecture, Central Japan
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DOI：
10.1207/s15327914nc381_3
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发表时间：
2000-09
期刊：
影响因子：
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通讯作者：
K. Wakai;Munehisa Takashi;K. Okamura;H. Yuba;Koh-ichi Suzuki;T. Murase;K. Obata;H. Itoh;Takanori Kato;M. Kobayashi;T. Sakata;Toshikazu Otani;Shin-ichi Ohshima;Y. Ohno
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文献类型：
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作者：
K. Wakai;Munehisa Takashi;K. Okamura;H. Yuba;Koh-ichi Suzuki;T. Murase;K. Obata;H. Itoh;Takanori Kato;M. Kobayashi;T. Sakata;Toshikazu Otani;Shin-ichi Ohshima;Y. Ohno
为了阐明饮食在膀胱癌病因中的作用，我们于1996年至1999年在日本中部的爱知县进行了一项病例对照研究。病例为新诊断为膀胱癌的患者，每个病例选择一个医院对照，匹配性别、年龄和医院。采用有效的食物频率问卷来估计营养素和食物类别的摄入量。使用条件Logistic模型计算调整了吸烟和职业史的优势比(OR)。基于297个病例和295个对照的分析揭示了以下结论。1)牛奶和乳制品摄入量越多，OR值越低，四分位数OR值分别为1.02、0.73和0.52。水果摄入量与风险呈负相关，尤其是在男性中(四分位数的OR=0.76、0.77和0.52)。在男性中，绿黄色蔬菜的消费量最高的四分位数与风险降低相关(OR=0.57)。2)在所有受试者中，饮食中摄取视黄醇和饱和脂肪酸与降低风险有关(四分位数的OR值分别为0.75、0.54和0.66和0.55、0.54和0.60)。单不饱和脂肪酸与男性膀胱癌风险呈负相关。
To elucidate the role of diet in the etiology of bladder cancer, we conducted a case-control study from 1996 to 1999 in Aichi Prefecture, Central Japan. Cases were patients newly diagnosed with bladder cancer, and one hospital control was selected for each case, matching gender, age, and hospital. A well-validated food frequency questionnaire was adopted to estimate intakes of nutrients and food groups. Odds ratios (ORs) adjusted for smoking and occupational history were computed using conditional logistic models. The analyses based on 297 cases and 295 controls revealed the following. 1) The more the intake of milk and dairy products, the lower the OR; the ORs across quartiles in all subjects were 1.02, 0.73, and 0.52. Fruit intake was negatively associated with the risk, particularly in men (ORs across quartiles = 0.76, 0.77, and 0.52). Green-yellow vegetables were associated with a decreased risk in the highest quartile of consumption in men (OR = 0.57). 2) Dietary intakes of retinol and saturated fatty acids were related to a reduced risk in all subjects (ORs across quartiles = 0.75, 0.54, and 0.66 and 0.55, 0.54, and 0.60, respectively). Monounsaturated fatty acids had an inverse association with bladder cancer risk in men.