Regiospecific synthesis of distally chlorinated ketones via C-C bond cleavage of cycloalkanols
Regiospecific synthesis of distally chlorinated ketones via C-C bond cleavage of cycloalkanols
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通过环烷醇 C−C 键断裂区域特异性合成远端氯化酮
DOI：
10.1039/c5qo00368g
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发表时间：
2016-01-01
影响因子：
5.4
通讯作者：
Zhu, Chen
中科院分区：
文献类型：
--
作者：
Fan, Xuefeng;Zhao, Huijun;Zhu, Chen
在温和的反应条件下，通过银催化环烷醇开环合成了多种具有良好区域选择性的远端csp3氯化酮。该反应仅使用常规、廉价的试剂，并且可以按比例增加到克量。提出了一种新的自由基介导的C-C键裂解/ C-Cl键形成。
A variety of distally Csp3-chlorinated ketones are synthesized with good regioselectivities via silver-catalyzed ring opening of cycloalkanols under mild reaction conditions. The reaction uses only routine, inexpensive reagents and can be scaled up to gram quantities. A novel radical-mediated C–C bond cleavage/C–Cl bond formation is proposed.