Intraductal low papillary histological pattern of carcinoma component shows intraductal spread in invasive carcinoma of the pancreas.
Intraductal low papillary histological pattern of carcinoma component shows intraductal spread in invasive carcinoma of the pancreas.
复制标题
癌成分的导管内低乳头状组织学模式显示胰腺浸润性癌的导管内扩散。
DOI：
--
复制
发表时间：
2006
期刊：
影响因子：
--
通讯作者：
B. Nobukawa
中科院分区：
文献类型：
--
作者：
Hirofumi Tanase;K. Suda;Shigetaka Yamasaki;B. Nobukawa
背景/目的
我们试图通过比较导管内成分和静脉侵犯的组织学模式来区分胰腺原位癌（CIS）和导管内侵犯/侵袭性导管癌（IDC）的癌化。
方法
对 30 名 IDC 患者的标本进行了组织病理学检查。在用苏木精和曙红以及 Elastica van Gieson (EVG) 染色的标本中评估 IDC 的导管内成分和血管侵犯。
结果
30 例 IDC 中，有 28 例发现 IDC 导管内成分，261 根导管中发现 IDC 导管内成分，平均每 1 例病例每一段有 2.3 根导管。 IDC的导管内成分分为三种组织学类型：低乳头状（包括扁平状）、管状（包括实性和筛状）和混合型（低乳头状+管状）。 261 个导管中低乳头状、管状和混合型的发生率分别为 39%（102 个导管）、56%（145 个导管）和 5%（14 个导管）。 26 例中除 1 例外，静脉侵犯的组织学形态均为管状，这 1 例显示低乳头状形态和管状形态。
结论
胰腺 IDC 中导管内成分的管状模式表明导管内侵犯，而低乳头状模式表明 CIS 或癌已扩散到其他位置。
BACKGROUND/PURPOSE
We attempted to discriminate between carcinoma in situ (CIS) and the intraductal invasion/cancerization of invasive ductal carcinoma (IDC) of the pancreas, by comparing the histological patterns of the intraductal components and those of venous invasion.
METHODS
Specimens from 30 patients with IDC were examined histopathologically. Intraductal components and blood vessel invasion in IDC were assessed in specimens stained with hematoxylin & eosin and elastica van Gieson (EVG).
RESULTS
Intraductal components of IDC were found in 28 of the 30 cases of IDC, in 261 ducts, and in 2.3 ducts per one section of one case, on average. The intraductal components of IDC were classified into three histological patterns, as follows: low papillary (including flat), tubular (including solid and cribriform), and mixed (low papillary plus tubular). The incidences of the low papillary, tubular, and mixed patterns in the 261 ducts, were 39% (102 ducts), 56% (145 ducts), and 5% (14 ducts), respectively. The histological pattern of venous invasion was tubular in all but 1 of the 26 cases, and this 1 case showed low papillary patterns as well as a tubular pattern.
CONCLUSIONS
A tubular pattern of intraductal components in IDC of the pancreas indicates intraductal invasion, while a low papillary pattern indicates CIS or carcinoma in another location to which it has spread.