Patients with sickle cell disease have increased sensitivity to cold and heat
Patients with sickle cell disease have increased sensitivity to cold and heat
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DOI：
10.1002/ajh.23341
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发表时间：
2013-01-01
影响因子：
12.8
通讯作者：
Panepinto, Julie A.
中科院分区：
文献类型：
--
作者：
Brandow, Amanda M.;Stucky, Cheryl L.;Panepinto, Julie A.
镰状细胞病（SCD）疼痛与较冷的温度和触摸有关，并被描述为冷、热和射击，表明对触觉刺激过敏。与对照组相比，镰状小鼠表现出对热（冷、热）和机械刺激的超敏反应。目前尚不清楚人类是否也有同样的超敏反应。因此，我们量化了SCD患者和对照组之间的热和机械敏感性差异。我们的主要假设是，与种族匹配的对照组相比，SCD患者会表现出对热刺激和机械刺激的超敏反应。我们的第二个假设是，这种过敏将与老年人和女性受试者有关，并与SCD患者的频繁疼痛和溶血有关。共55例患者和57例对照组=7年完成定量感觉测试。SCD患者检测到寒冷的感觉和温暖的气温早在他们中间冷和热探测阈值明显降低(29.5度和28.6度C、P = 0.012和34.5度和35.3度C, P = 0.02)和有经验的冷和热疼痛早在他们中间冷和热痛阈值明显降低(21.1度和14.8度C、P = 0.01和42.7度和45.2度C, P = 0.04)。我们没有发现机械阈值差异。两组患者年龄越大，冷、热、机械痛阈值越低。与疼痛、性别或溶血无关联。SCD患者表现出对热刺激的超敏反应，表明可能存在外周或中枢致敏，并可能导致SCD疼痛。点。血液学杂志。2013。(c) 2012 Wiley期刊有限公司
Sickle cell disease (SCD) pain is associated with colder temperatures and touch and described as cold, hot, and shooting suggesting hypersensitivity to tactile stimuli. Sickle mice exhibit hypersensitivity to thermal (cold, heat) and mechanical stimuli compared to controls. It is unknown whether humans experience this same hypersensitivity. Thus, we quantified thermal and mechanical sensitivity differences between patients with SCD and controls. Our primary hypothesis was that patients with SCD will exhibit hypersensitivity to thermal and mechanical stimuli compared to race-matched controls. Our secondary hypothesis was this hypersensitivity will be associated with older and female subjects, and with frequent pain and hemolysis in patients with SCD. A total of 55 patients and 57 controls =7 years completed quantitative sensory testing. Patients with SCD detected the sensation of cold and warm temperatures sooner as seen in their significantly lower median cold and heat detection thresholds [29.5 degrees C vs. 28.6 degrees C, P = 0.012 and 34.5 degrees C vs. 35.3 degrees C, P = 0.02] and experienced cold and heat pain sooner as seen in their significantly lower median cold and heat pain thresholds [21.1 degrees C vs. 14.8 degrees C, P = 0.01 and 42.7 degrees C vs. 45.2 degrees C, P = 0.04]. We found no mechanical threshold differences. Older age was associated with lower cold, heat, and mechanical pain thresholds in both groups. No association with pain, gender, or hemolysis was found. Patients with SCD exhibit hypersensitivity to thermal stimuli suggesting peripheral or central sensitization may exist and could contribute to SCD pain. Am. J. Hematol. 2013. (c) 2012 Wiley Periodicals, Inc.